Abstract
A 51-year-old man was found to have hepatic metastasis from colon carcinoma. Bone scintigraphy with99mTc-hydroxymethylene diphosphonate showed a ringlike accumulation corresponding to the hepatic mass, which was without calcification on computed tomography. Treatment with chemotherapeutic agents was started. After 4 months, computed tomography showed that the mass was smaller than before and that the margin was calcified. The extraosseous accumulation of the radionuclide may be evidence supporting earlier speculation on calcification that could not yet be detected by computed tomography.
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Poulose KP, Reba RC, Eckelman WC, Goodyear M. Extraosseous localization of99mTc-Sn pyrophosphate.Br J Radiol 48: 724–726, 1975.
Guiberteau MJ, Potsaid MS, McKusick KA. Accumulation of99mTc-diphosphonate in four patients with hepatic neoplasm: case reports.J Nucl Med 17: 1060–1061, 1976.
Garcia AC, Yeh SDJ, Benua RS. Accumulation of boneseeking radionuclides in liver metastases from colon carcinoma.Clin Nucl Med 2: 265–269, 1977.
Romyn AM, Bushnell DL, Freeman ML, Kaplan E. Visualization of metastatic liver disease on technetium-99m bone scintigraphy.Clin Nucl Med 12: 264–267, 1987.
Wayslewski A-H, Furst G, Schmitt G. Liver uptake of99mTc-labeled diphosphonate (DPD) by metastatic lesions from large bowel carcinoma.Eur J Nucl Med 10: 467–468, 1985.
Shih W-J, Domstad PA, Lieber A, DeLand FH, Coupai JJ. Localization of99mTc-HMDP in hepatic metastases from colonic carcinoma.Am J Roentgenol 146: 333–336, 1986.
Senda M, Tamaki N, Torizuka K, Fujiwara Y, Kudo M, Tochio H, et al. Accumulation of Tc-99m methylene diphosphonate in calcified metastatic lesions of the liver from colonic carcinoma: comparison with calcification on X-ray computed tomogram.Clin Nucl Med 10: 9–12, 1985.
Baumerti JE, Lantieri RL, Horning S, McDougall IR. Liver metastases of breast carcinoma detected on99mTc-methylene diphosphonate bone scan.Am J Roentgenol 134: 384–391, 1980.
Marsh JI, Belzberg ASB, Murphy KC. Uptake of technetium-99m diphosphonate by metastatic large cell carcinoma of the lung.J Nucl Med 29: 726–728, 1988.
Lowenthal IS, Tow DE, Chang YC. Accumulation of99mTcpolyphosphate in two squamous cell carcinomas of the lung: Case report.J Nucl Med 16: 1021–1023, 1975.
Yeh S-H, Shih W-J, Liang J-C. Intravenous radionuclide hepatography in the differential diagnosis of intrahepatic mass lesions.J Nucl Med 14: 565–567, 1973.
Kim EE. Ring sign in radionuclide cerebral images.Semin Nucl Med11: 168–169, 1981.
Selkirk JK, Elwood JC, Morris HP. Study on the proposed role of phospholipid in tumor cell membrane.Cancer Res 31: 27–31, 1971.
Ghose T, Nairn RC, Fothergill JE. Uptake of proteins by malignant cells.Nature 196: 1108–1109, 1962.
Harper PV, Lathrop KA, Jiminez F, Fink R, Gottschalk A. Technetium 99m as a scanning agent.Radiology 85: 101–108, 1965.
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Shiomi, S., Kuroki, T., Hasegawa, I. et al. Accumulation of Tc-99m HMDP in hepatic metastasis from colon carcinoma without detectable calcification. Ann Nucl Med 10, 347–349 (1996). https://doi.org/10.1007/BF03164744
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DOI: https://doi.org/10.1007/BF03164744