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Expression of p53, Ki-67 and Bcl-2 in parathyroid adenoma and residual normal tissue

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Pathology & Oncology Research

Abstract

The aim of this study was to investigate the expression of Ki-67, bcl-2 and p53 in parathyroid adenomas and their residual rim of normal parathyroid tissue. Specimens from 26 parathyroid adenomas were studied by immunohistochemical analysis for Ki-67, bcl-2 and p53 expression. Positive findings were noted for p53 in 4 (15%) adenomas and none of the residual rims of normal parathyroid tissue (p = 0.055); for Ki-67 in 15 (56%) adenomas and none of the residual rims of normal parathyroid tissue (p = 0.00002); and for bcl-2 in 19 (73%) adenomas and 8 (31%) residual rims of normal parathyroid tissue (p < 0.01). The high rate of Ki-67 expression may indicate susceptibility of parathyroid adenomas to clonal proliferation. The weak immunoreactive expression of p53, combined with a relatively strong expression of bcl-2, may contribute to the characteristic slow progression of these tumors.

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Authors and Affiliations

  1. Departments of Otolaryngology-Head and Neck Surgery, Rabin Medical Center, Petah Tikva and Sackler Faculty of Medicine, Tel Aviv University, Israel

    Tuvia Hadar, Jacob Shvero, Eitan Yaniv & Itzhak Shvili

  2. Department of Surgery A, Rabin Medical Center, Petah Tikva and Sackler Faculty of Medicine, Tel Aviv University, Israel

    Eduard Ram

  3. Department of Pathology, Rabin Medical Center, Petah Tikva and Sackler Faculty of Medicine, Tel Aviv University, 69978, Ramat Aviv, Tel Aviv, Israel

    Rumelia Koren

Authors
  1. Tuvia Hadar
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  2. Jacob Shvero
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  3. Eitan Yaniv
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  4. Eduard Ram
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  5. Itzhak Shvili
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  6. Rumelia Koren
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Correspondence to Rumelia Koren.

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Hadar, T., Shvero, J., Yaniv, E. et al. Expression of p53, Ki-67 and Bcl-2 in parathyroid adenoma and residual normal tissue. Pathol. Oncol. Res. 11, 45–49 (2005). https://doi.org/10.1007/BF03032405

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  • DOI: https://doi.org/10.1007/BF03032405

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