Abstract
Objective
It is important to estimate the bone metabolism in patients with renal osteodystrophy. The methods of estimation must be noninvasive, accurate, and able to measure repeatedly.
Methods
The regions of interest on bone scintigraphy were drawn over the radius in 22 hemodialysis patients (10 males, 12 females). The bone/soft tissue ratio (B/ST ratio) was calculated for all patients. The bone soft tissue ratio of both skull (S) and radius (R) was obtained from the resultant count ratios. We investigated the correlation between intact parathyroid hormone (PTH), alkaline phosphatase (ALP) and the uptake ratios S and R.
Results
Intact PTH had a significantly linear correlation with R (r = 0.745, p < 0.0001) and S (r = 0.702, p = 0.0001). ALP also had a significantly linear correlation with R (r = 0.537, p = 0.009) and S (r = 0.772, p < 0.0001).
Conclusion
The measurement of the bone soft tissue ratio of radius on bone scintigraphy was crucial for estimating renal osteodystrophy.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
de Jonge FA, Pauwels EK, Hamby NA. Scintigraphy in the clinical evaluation of disorders of mineral and skeletal metabolism in renal failure.Eur J Nucl Med 1991; 18: 839- 855.
Rosenthall L. Radiophosphate imaging and bone densitom- etry in renal osteodystrophy.Curr Opin Nephrol Hypertense 1993; 2: 956–961.
Kobashi T, Okamura T, Ochi H, Hagiwara S, Onoyama Y. Comparison of bone scans, parathyroid hormone levels and bone mineral densities in hemodialysis patients.Miner Electrolyte Metab 1995; 21: 114–119.
Israel O, Gips S, Lubushitzky R, Bettman L, losilevsky G, Hardoff R, et al. Prediction of bone loss in patients with primary hyperparathyroidism using quantitative bone SPECT.J Nuc Med 1998; 39: 1614–1617.
Israel O, Lubushitzky R, Frenkel A, losilevsky G, Bettman L, Gips S, et al. Bone turnover in cortical and trabecular bone in normal woman and in woman with osteoporosis.J Nucl Med 1994; 35: 1155–1158.
Rosenthall L, Kaye M. Observations on the mechanism of99mTc-labeled phosphate complex uptake in metabolic bone disease.Semin Nucl Med 1976; 6: 59–67.
Fleish H, Russell RG. Experimental clinical studies with pyrophosphate and diphosphonates. In:Calcium metabolism in renal failure and nephrolithiasis, David DS, ed. New York; Wiley, 1977: 293–336.
Fogelman I, Bessent RG, Gordon D. A critical assessment of bone scans quantitation (bone to soft tissue ratios) in the diagnosis of metabolic bone disease.Eur J Nucl Med 1981; 6: 93–97.
Fogelman I, Bessent RG, Turner JG, Citrin DL, Boyle IT, Greig WR. The use of whole-body retention of Tc-99m diphosphonate in the diagnosis of metabolic bone disease.J Nucl Med 1978; 19: 245–248.
Sy WM, Mittal AK. Bone scan in chronic dialysis patients with evidence of secondary hyperparathyroidism and renal osteodystrophy.Br JRadiol 1975; 48: 878–884.
de Graff P, Schicht IM, Pauwels EK, te Velde J, de Graff J. Bone scintigraphy in renal osteodystrophy.J Nucl Med 1978; 19: 1289–1296.
Olgaard K, Heerfordt J, Madsen S. Scintigraphic skeletal changes in uremic patients on regular hemodialysis.Neph- ron 1976; 17: 325–334.
Fogelman I, Carr D. A comparison of bone scanning and radiology in the evaluation of patients with metabolic bone disease.Clin Radiol 1980; 31: 321–326.
Johnson LC. Morphologic analysis in pathology: the kinetics of disease and general biology of bone. In:Bone Biodynamics, Frost HM, ed., 1st ed. Boston; Little, Brown & Co., 1964: 543–654.
Schober HC, Han ZH, Foldes AJ, Shin MS, Rao DS, Balena R, et al. Mineralized bone loss at different sites in dialysis patients. Implication for prevention.J Am Soc Nephrol 1988; 9: 1225–1233.
Gabey C, Ruedin P, Slosman D, Bonjour JP, Leski M, Rizzoli R. Bone mineral density in patients with end-stage renal failure.Am J Nephrol 1993; 13: 115–123.
Ozdemir H, Ozdemir A, Soyucu Y, Urguden M. The role of bone scintigraphy in determining the etiology of heel pain.Ann Nucl Med 2002; 16: 395–401.
Kurata S, Ishibashi M, Nishida H, Hiromatsu Y, Hayabuchi N. A clinical assessment of the relationship between bone scintigraphy and serum biochemical markers in hemodialysis patients.Ann Nucl Med 2004; 18: 513–518.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Nishida, H., Kaida, H., Ishibashi, M. et al. Usefulness of bone uptake ratio of bone scintigraphy in hemodialysis patients. Ann Nucl Med 19, 91–94 (2005). https://doi.org/10.1007/BF03027386
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF03027386