Skip to main content
Log in

Recent advances in the molecular biology of head and neck tumours

  • Published:
Indian Journal of Otolaryngology and Head and Neck Surgery Aims and scope Submit manuscript

Abstract

Our knowlcwdge about the genetic basis of head and neck tumours is accumulating fast. This article reviews the important advances in this area over the last decade and its implications for the future. Newer aspects of gene therapy, molecular staging and understanding head and neck carcinogenesis on a molecular level are outlined.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Renan M J, (1993): How many mutations are required for tumorigenesis ? Implications from human cancer data. Mol Carcinogenesis 7: 139–146

    Article  CAS  Google Scholar 

  2. Pardee A B (1989): G1 events and regulation of cell proliferation. Science, 246: 603–608.

    Article  CAS  PubMed  Google Scholar 

  3. Sidransky D, Brennan J A et al: (1995) Molecular assessment of histopathologic staging in Head and Neck Squamous Cell Carcinoma. Current Opinion in Otolaryngology-Head and Neck Surgery, vol. 332, no. 7, pp 429–434.

    Google Scholar 

  4. Dolcetti R, Doglino C, et al (1993) p53 is an early event in the development of human Squamous cell carcinoma of the larynx: genetic and prognostic implications. Int J Cancer, 52: 178–182.

    Article  Google Scholar 

  5. Pruneri C, Pignatoro L et al (1994) p53 protein expression in laryngeal squamous cell carci-noma bearing wild-type and mutated p53 gene. Histopathology 28: 513–519.

    Article  Google Scholar 

  6. Jares P, Fernandez P L et al (1994) PRAD-1/Cyclin D1 gene amplification correletes with tumour progression in human laryngeal carcinomas. Cancer Res., 54: 4813–17.

    CAS  PubMed  Google Scholar 

  7. Callendu J, el-Nagger AG, Li M S et al (1994) PRAD-1/Cyclin D1 oncogene amplification in primary HNSCC. Cancer, 74: 152–8.

    Article  Google Scholar 

  8. Sidransky D: Molecular genetics of head and neck cancer (1995). Current Opinion in Oncology; 1995, 7:229–233.

    Article  CAS  PubMed  Google Scholar 

  9. Speicher MK, Howe C et al (1995) Comparative genomic hybridization detects novel dele-tions and amplifications in HNSCC. Cancer Research; Marl,55(5):1010–3.

    CAS  Google Scholar 

  10. Scott-Brown’s Otolaryngology vol. 1: Cell Biology; Wilson S Mertens, 1/20/6 pp.6

  11. Field JK (1992); Oncogenes in Tumour Suppressor Genes in squamous cell carcinoma in the head and neck. Oral Oncology, European J of Cancer, 28B, 67–76.

    Article  CAS  Google Scholar 

  12. Eversole L R, Sapp JP (1993); Oncogenes and tumour suppressor genes in squamous cell carcinoma of the head and neck; Oral Oncology, European J of Cancer.

  13. Clarke Louis J (1996); Clinical Genetics of Head and Neck Cancer; CME Bulletin, Otorhinolaryng-ology, vol 1: no. 1, Oct, pp 12–15.

    Google Scholar 

  14. Grandis JR, Tweardy D J (1998); Elevated levels of TGF-a and EFGR m-RNA are early mark-ers of carcinomma in HNSCC. Cancer Res; 53: 3579–84.

    Google Scholar 

  15. Grandis JR, Melhem MF et al (1998); Levels of TGF-a and EFGR protein in HNSCC and patient survival. J Natl Cancer Institute; 90(11): 824–32.

    Article  Google Scholar 

  16. Nin F (1998); Immunohistological studies on growth potential of head and neck carcinomas] Nippon Jibiinkoka Gakkai Kaiho; 101(3):312–326.

    CAS  PubMed  Google Scholar 

  17. Hoffman T, Hafner D et al(1997); Anti-tumour activity of EFGR antibodies and cispktin in 10 human HNSCC lines. Anticancer Res; 17(6D): 4419–4425.

    Google Scholar 

  18. Gasparotto D, Maestro R et al: Overexpression of CDC 25 A CDC 25 B in head and neck cancers. Cancer Research 57 (12):2366–8.

  19. Oliner JD, Pietenpol J A et al : Oncoprotein MDM-2 conceals the activation domain of tumour suppressor p53. Nature : 362: 857.

  20. Pignataro L, Cappacio P et al: The predictive value ofp53, MDM-2, cyclin D1 and Ki-67 in the progression of low-grade dysplasia towards carcinoma of larynx. JLO, vol. 112, pp. 455–459.

  21. Hollstein M, Sidransky D et al (1991): p53 mutations in human cancer. Science: 253: 49–53.

    Article  CAS  PubMed  Google Scholar 

  22. Whistler L C, Wood N B et al(1998); Regulators of proliferation and apoptosis in carcinoma of larynx. 630–638.

  23. Kernohan NM, Cor L S(1996); Regulation ofapoptsis by bcl-2 and related proteins: immuno- logical challenges and therapeutic applications. J of pathology, 179 :1–3.

    Article  CAS  Google Scholar 

  24. Ahomadegbe JC, Barrois M et al(1995); High incidence of p53 alterations in Head and Neck primary tumours and metastases; frequent protein overexpression in normal epithelium and in early non-invasive lesions. Oncogene: 10: 1217–27.

    CAS  PubMed  Google Scholar 

  25. Bradford C R, Zhu S et al(1997); p53 mutations in advanced laryngeal cancer. Archives of Otol. H & N Surgery. 123(6): 605–9.

    CAS  Google Scholar 

  26. Gonzalez M V, Pello M F et al (1997); Deletion and methylation of tumour suppressor genes in primary HNSCC. J Clin Pathol 50(6)509–512.

    Article  CAS  PubMed  Google Scholar 

  27. Narayana A, Vaughan AT et al(1998); Is p53 an independent prognostic factor in patients with laryngeal carcinoma ? Cancer: 80(2) :286–91.

    Article  Google Scholar 

  28. Nogueira CP, Dolan RW et al(1998); Inactivation of p53 and amplification of cyclin D1 correlate with clinical outcome in head and neck cancers. Laryngoscope 108 (3):345–50.

    Article  CAS  PubMed  Google Scholar 

  29. Couturier J, Sartre-Garan X et al: Integration of papilloma virus DNA near myc genes in genital carcinoma and its consquences for proto-oncogene expression. 1991 :J of Virology, 65, 4534–38.

    CAS  Google Scholar 

  30. Mackaig RG, Baric RS, Olshan AF (1998); HPV and Head and Neck cancer: Epidemiology and molecular biology, 1998; Head-Neck, 20(3):250–265.

    Article  Google Scholar 

  31. Frixen U, Behrens J et al(1991); E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cell. J of Cell Biology; 113, 173–185.

    Article  CAS  Google Scholar 

  32. MacDonald NJ et al(1993); A novel phosphorylation of nm23, not its NDPK activity corre-lates with metastatic potential; Proceedings of the American Association of Cancer Re-search; 1993:34,A393.

    Google Scholar 

  33. Chambers A F, Tuck A B(1993); Ras-responsive genes and tumour metastasis. Critical Re-views in Oncogenesis 4, 95–114.

    CAS  Google Scholar 

  34. Rak J, Filmus J et al(1995); Oncogenes as inducers of tumour angiogenesis. [Review] [85 references. Cancer and Metastasis Reviews. 14(4): 263–77

    Article  CAS  PubMed  Google Scholar 

  35. Gallo O, Masini E et al: Role of nitric oxide in angiogenesis and tumour progression, 1998 April: I Natl Cancer Institute; 90(8): 587–96.

  36. Boyle JB, Mao L et al (1994); Gene mutations in saliva a molecular markers HNSCC. Am J Surgery: 168:429–432.

    Article  CAS  Google Scholar 

  37. dayman GL, el-Naggar AL et al : Adenovirus-mediated p53 gene transfer in patients with advanced HNSCC. J Clin Oncol; 16(6):222–2232.

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bhattacharyya, A.K., Ghosh, S. Recent advances in the molecular biology of head and neck tumours. Indian J Otolaryngol Head Neck Surg 51, 10–18 (1999). https://doi.org/10.1007/BF03022707

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03022707

Key Words

Navigation