Résumé
Les auteurs étudient chez 10 chiens les effets de débits croissants d’alfatésine sur la ventilation (Ve, fréquence, Vt, gaz du sang), sur le régime ventilatoire (Ti, Te, Ti/Tlot), sur la neurogénèse ventilatoire (Vt/Ti , pression d’occlusion à0.5 secondes) et sur le réflexe de Breuer-Hering (durée de l’apnée après occlusion des voies aériennes en fin d’inspiration). Les résultats ont été comparés aux valeurs normales relevées dans la littérature. Une corrélation a été recherchée entre le débit d’alfatésine et les différents paramètres mesurés ou calcués. Pour de faibles débits d’alfatésine la ventilation est stimulée, stimulation traduite essentiellement par une tachypnée sans modification de Vt. L’approfondissement de l’anesthésie s’accompagne d’une dépression respiratoire progressivement croissante (diminution de Ve, de la fréquence, de Vt/Ti, de P 0.5, augmentation de la Paco2 et de la durée d’apnée). Les mécanismes de la stimulation ventilatoire initiale et de la dépression respiratoire sont discuss. Les auteurs concluent que l’action centrale de l’alfatésine est une stimulation du systeme nerveux central en cas d’anesthésie légère, puis une dépression croissante en fonction de la profondeur de l’anesthésie.
Abstract
In 10 dogs the authors studied the effects of increasing doses of alfathesin on ventilation (Ve, frequency, Vt, blood gases), on the ventilatory pattern (Ti, Te, Ti/Ttot), on the neurological initiation of ventilation (Vt/Ti, occlusion pressure at 0.5 seconds), and on the Hering-Beurer reflex (duration of apnoea after occlusion of the airway at the end of inspiration). The results were compared with normal values taken from the literature. The correlation between the dose of alfathesin and the measured or calculated parameters was examined.
Ventilation was stimulated by low doses of alfathesin, a stimulation characterized by tachypnoea without change in tidal volume. Deepening of anaesthesia was accompanied by progressively increasing depression of respiration (diminution of Ve, of frequency, of Vt/Ti and increase of Paco2 and of the duration of apnoea).
The mechanisms of the initial stimulation of ventilation and of respiratory depression are discussed.
The authors conclude that the action of alfathesin on the central nervous system is biphasic, with stimulation during light anaesthesia followed by depression with associated depression of ventilation, despite increasing hypoxia and hypercapnia.
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Gaudy, JH., Dauthier, C., BoItier, JF. et al. Effets ventilatoires de debits croissants d’alfatesine chez le chien. Canad. Anaesth. Soc. J. 29, 600–611 (1982). https://doi.org/10.1007/BF03007748
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DOI: https://doi.org/10.1007/BF03007748