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Serial assessment of left ventricular performance at rest and during bicycle exercise by ECG-gated myocardial perfusion SPECT

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Abstract

The present study evaluates left ventricular performance during exercise by ECG-gated myocardial perfusion SPECT with short-time data collection. Methods: The study population consisted of 10 healthy volunteers (Group N) and 9 patients with ischemic heart disease (Group I). Seven patients in Group I had a history of prior myocardial infarction. Rest ECG-gated SPECT was performed 40 min after an injection of Tc-99m-tetrofosmin (555–740 MBq). After resting data acquisition, Group N underwent up to two 5-min stages of exercise (75 and 125 watts) on a detachable bicycle ergometer. The Group I patients all underwent symptom-limited, maximal testing on the ergometer. ECG-gated SPECT data were acquired from both groups for 3 min at rest and during the last 3 min of each exercise stage. Results: Significant increases occurred in LVEF from rest to peak stress in both groups (from 55.4±5.8 to 66.6±4.1% in group N, p<0.0001; from 49.0±12.8 to 56.7±13.8% in Group I, p<0.001). The LVESV values significantly decreased to peak stress in Group N (from 49.9±13.1 to 37.8±10.0 ml, p<0.0001), whereas LVEDV did not change (from 110.6±18.9 to 112.0±19.0 ml). In contrast, the LVESV values at rest and under peak stress were similar in Group I (from 52.6±23.9 to 51.7±31.4 ml) and LVEDV in Group I at peak exercise tended to increase (from 102.8±36.7 to 111.3±39.0 ml). The changes in LVESV from rest to peak stress were significantly different between Groups N and I (−12.1±6.3 vs.−0.9±11.6 ml, p<0.02). Conclusion: ECG-gated SPECT with short-time data collection can assess left ventricular function during exercise and may offer useful information for evaluating patients with ischemic heart disease.

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Authors and Affiliations

  1. Department of Radiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyoku, 113-8603, Tokyo, Japan

    Shin-ichiro Kumita, Keiichi Cho, Hidenobu Nakajo, Masahiro Toba, Kazuyoshi Akiyama, Yoshimitsu Fukushima, Sunao Mizumura & Tatsuo Kumazaki

  2. First Department of Internal Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyoku, 113-8603, Tokyo, Japan

    Junko Sano, Kazuo Munakata, Hiroshi Kishida & Teruo Takano

Authors
  1. Shin-ichiro Kumita
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  2. Keiichi Cho
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  3. Hidenobu Nakajo
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  4. Masahiro Toba
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  5. Kazuyoshi Akiyama
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  6. Yoshimitsu Fukushima
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  7. Sunao Mizumura
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  8. Tatsuo Kumazaki
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  9. Junko Sano
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  10. Kazuo Munakata
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  11. Hiroshi Kishida
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  12. Teruo Takano
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Correspondence to Shin-ichiro Kumita.

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Kumita, Si., Cho, K., Nakajo, H. et al. Serial assessment of left ventricular performance at rest and during bicycle exercise by ECG-gated myocardial perfusion SPECT. Ann Nucl Med 16, 329–335 (2002). https://doi.org/10.1007/BF02988617

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  • DOI: https://doi.org/10.1007/BF02988617

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