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Anticomplement activities of oleanolic acid monodesmosides and bisdesmosides isolated fromTiarella polyphylla

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Abstract

Seven known oleanolic acid glycosides (1–7) were isolated from the MeOH extract ofTiarella polyphylla. The structures were identified to be 3-O-(β-D-glucopyranosyl) oleanolic acid (1), 3-O-[β-D-glucopyranosyl-(1→3)-β-D-glucopyranosyl] oleanolic acid (2), 3-O-[β-D-glucopyranosyl-(1→2)-β-D-glucopyranosyl] oleanolic acid (3), 3-O-[β-D-glucopyranosyl-(1→3)-β-D-glucopyranosyl] oleanolic acid 28-O-β-D-glucopyranosyl ester (4), 3-O-[β-D-glucopyranosyl-(1→2)-β-D-glucopyranosyl] lleanolic acid 28-O-β-D-glucopyranosyl ester (5), 3-O-[a-L-rhamnopyranosyl-(1→3)-β-D-glucuronopyranosyl] oleanolic acid (6), and 3-O-[α-L-rhamnopyranosyl-(1→3)-β-D-glucuronopyranosyl] oleanolic acid 28-O-β-D-glucopyranosyl ester (7) on the basis of physicochemical and spectral data. These triterpene glycosides were tested for the anticomplement activity and hemolytic activity. Bisdesmosidic saponins,4, 5, and7, showed anticomplement activity; in contrast, monodesmosidic saponins,1–3, and6, showed direct hemolytic activity. Methyl esterified monodesmosidic saponins showed anticomplement activity at a low concentration and hemolytic activity at a high concentration.

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Authors and Affiliations

  1. Natural Product Biosynthesis Research Unit, Korea Research Institute of Bioscience & Biotechnology, Yusong, P. O. Box 115, 305-600, Taejon, Korea

    Si-Hyung Park, Sei Ryang Oh, Keun Young Jung, Im Seon Lee, Kyung Seop Ahn, Jung Joon Lee & Hyeong-Kyu Lee

  2. Institute of Natural Drug Resources, 360-060, Cheongju, Korea

    Jae-Gil Kim

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  1. Si-Hyung Park
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  2. Sei Ryang Oh
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  3. Keun Young Jung
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  4. Im Seon Lee
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  5. Kyung Seop Ahn
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  6. Jae-Gil Kim
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  7. Jung Joon Lee
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  8. Hyeong-Kyu Lee
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Correspondence to Hyeong-Kyu Lee.

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Park, SH., Oh, S.R., Jung, K.Y. et al. Anticomplement activities of oleanolic acid monodesmosides and bisdesmosides isolated fromTiarella polyphylla . Arch Pharm Res 22, 428–431 (1999). https://doi.org/10.1007/BF02979071

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  • DOI: https://doi.org/10.1007/BF02979071

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