Abstract
A modified procedure of a previous synthetic route for baicalein was developed in order to obtain more than ten grams of baicalein forin vivo test. There were several difficulties in applying the published experimental procedures for a large scale of synthesis. The modified synthetic work was successfully accomplished by reducing amount of strong Lewis acid in Fries rearrangement and using tetrabutylammonium iodide as an additive to speed up the demethylation reaction in refluxing HBr into completion.
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Kim, S., Sohn, D.W., Kim, Y.C. et al. Fine tuning of a reported synthetic route for biologically active flavonoid, baicalein. Arch Pharm Res 30, 18–21 (2007). https://doi.org/10.1007/BF02977773
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DOI: https://doi.org/10.1007/BF02977773