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Noble 2-[3-(cyclopentyloxy)-4-methoxyphenyl]-1 -isoindolinone derivatives. Part I: synthesis and SAR studies for the inhibition of TNF-α production

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  • Medicinal Chemistry & Natural Products
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Abstract

This study describes the synthesis andin vitro evaluation of noble 2-[3-(cyclopentyloxy)-4-methoxyphenyl]-1-isoindolinone derivatives for the inhibition of TNF-α production. Among these compounds, 2-[3-(cyclopentyloxy)-4-methoxyphenyl]-3-methyl-1 -isoindolinone (5) was the most potent in inhibitory activity of TNF-α production in LPS-stimulated RAW264.7 cells.

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References

  • Cho, J. Y., Park, J., Yoo, E. S., Yoshikawa, K., Baik, K. U., Lee, J. S., and Park, M. H. Inhibitory effect of lignans from the rhizomes of Coptis japonica var. dissecta on tumor necrosis factor-alpha production in lipopolysaccharide-stimulated RAW264.7 cells.Arch. Pharm. Res., 21, 12–16 (1998).

    PubMed  CAS  Google Scholar 

  • Eigler, A., Sinha, B., Hartmann, G., andEndres, S. Taming TNF: strategies to restrain this proinflammatory cytokine.Immunology Today, 28, 487–492 (1997).

    Article  Google Scholar 

  • Garrison, L. andMcDonnell, N. D. Etanercept: therapeutic use in patients with rheumatoid arthritis.Ann. Rheum. Dis., 58, Suppl 1, 165–169 (1999).

    Google Scholar 

  • Harriman, G., Harper, L. K., andSchaible, T. F. Summary of clinical trials in rheumatoid arthritis using infliximab, an anti-TNF alpha treatment.Ann. Rheum. Dis., 58, Suppl 1, 161–164 (1999).

    Google Scholar 

  • Newton, R. C., andDecicco, C. P. Therapeutic potential and strategies for inhibiting tumor necrosis factoralpha.J. Med. Chem., 42, 2295–2314 (1999).

    Article  PubMed  CAS  Google Scholar 

  • Park, J. S., Baik, K. U., Son, H. J., Cho, J. Y., Park, J., Lee, J. H., Lee, S. J., Yoo, E. S., andPark, M. H. Syntheses and biological evaluation of novel compounds for the inhibition of TNF-α production.Kor. J. Med. Chem., 10, 6–9 (2000a).

    CAS  Google Scholar 

  • Park, J. S., Baik, K. U., Son, H. J., Cho, J. Y., Park, J., Lee, J. H., Lee, S. J., Yoo, E. S., Byun, Y. S., andPark, M. H. Synthesis and structure-activity relationships of novel compounds for the inhibition of TNF-α production.Arch. Pharm. Res., 23, 332–337 (2000b).

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Institute of Biosciences & Biotechnology, Daewoong Pharm Co. Ltd, 449-814, Yongin, Kyunggi-do, Korea

    Joon Seok Park, Kyong Up Baik, Jae Youl Cho, Eun Sook Yoo, Young Seok Byun & Myung Hwan Park

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  1. Joon Seok Park
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  2. Kyong Up Baik
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  3. Jae Youl Cho
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  4. Eun Sook Yoo
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  5. Young Seok Byun
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  6. Myung Hwan Park
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Correspondence to Joon Seok Park.

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Park, J.S., Baik, K.U., Cho, J.Y. et al. Noble 2-[3-(cyclopentyloxy)-4-methoxyphenyl]-1 -isoindolinone derivatives. Part I: synthesis and SAR studies for the inhibition of TNF-α production. Arch Pharm Res 24, 367–370 (2001). https://doi.org/10.1007/BF02975177

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  • DOI: https://doi.org/10.1007/BF02975177

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