Summary
CYTOPLASMIC estradiol receptors in human mammary carcinomas correlated with total protein, nuclear estradiol receptors, progesterone receptors and CEA but not with tumour levels of estrogens or progesterone. The proportion of estaradiol receptor positive tumours decreased with increasing stage, grade and lymphocyte infiltration of the tumours. Lobular carcinomas were more frequently receptor-positive than ductal carcinomas. Patients with estradiol receptor negative tumours had a significantly worse survival than patients with estradiol receptor positive tumours.
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This work was in part supported by both the Medical Research Council of Ireland and the Irish Cancer Society. We thank the Department of Endocrinology, St. Vincent’s Hospital for carrying out the estrogen and progesterone assays.
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Duffy, M.J., O’Connell, M., McDonnell, L. et al. Studies on estradiol receptors in human mammary carcinomas. I.J.M.S. 153, 381–384 (1984). https://doi.org/10.1007/BF02939800
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DOI: https://doi.org/10.1007/BF02939800