Summary
Plasma gastrin and secretin concentrations have been measured in umbilical cord and maternal blood at delivery. In contrast to previous reports, elevated levels were not found in cord blood, and maternal secretin values exceeded fetal. The physiological roles and some of the problems with measurement of these hormones is discussed.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Anysley-Green, A., Lucas, A., Bloom, S. R. 1979. The effect of feeds of differing composition on entero-insular hormone secretion in the first hours of life in human neonates. Acta Pediatr. Scand. 68, 265.
Davidson, D. C., Rogers, J. M., Ardill, J., Buchanan, K. D. 1975. Neonatal gastric hyperacidity. Further analysis of oxytocin effect. Archives of Disease in Childhood. 50, 818.
Delle Fave, G. F., Kohn, A., Bergonzi, L., Melchiorri, P., Torsoli, A. 1976. Gastrin plasma levels in human newborns. Acta Hepata-Gastroenterologica 23, 72.
Dockray, G. J. 1978. Gastrin overview.In: Gut Hormones. Ed. S. R. Bloom Edinburgh, Churchill Livingstone, 129.
Euler, A. R., Ament, M. E., Walsh, J. H. 1978. Human newborn hypergastrinaemia: an investigation of prenatal and perinatal factors and their e: ects on gastrin. Pediat. Res. 12, 652.
Häcki, W. H., Bloom, S. R., Mitznegg, W., Domschke, W., Domschke, S., Belohlavek, D., Demling, L., Wünsch, E. Plasma secretin and pancreatic bicarbonate response to exogenous secretin in man. Gut 18, 191.
Matsuhashi, K., Miyagami, J., Kanazawa, T., Yanaihara, T., Nakayama, T., Ganihara, C., Yanaihara, N. 1977. Immunoreactive secretin in pregnancy. Acta Endoc. 85 (S 212), 255.
Mckiernan, J., King, J. 1980. Plasma gastrin and secretin in pregnancy. J. Irish Med. Assoc. 5, 199.
Rayford, P. L., Miller, T. A., Thompson, J. C. 1976. Secretin, cholecystokinin and newer gastrointestinal hormones. N. Eng. J. Med. 214, 1093.
Rogers, J. M., Davidson, D. C., Lawrence, J., Buchanan, K. D. 1975. Neonatal secretion of secretin. Archives of Disease in Childhood 50, 120.
Rooney, P. J., Dow, T. G. B., Brooks, P. M., Dick, W. C., Buchanan, K. D. 1975. Immunoreactive gastrin and gestation. Am. J. Obstet. Gynecol. 122, 834.
Russell, R. C. G., Bloom, S. R., Fielding, L. P., Bryant, M. G. 1976. Current problems in the measurement of gastrin release. A reproducible measure of physiological gastrin release. Postgrad. Med. J. 52, 645.
Sann, L., Chayvialle, A. P., Bremond, A., Lambert, R. 1975. Serum gastrin level in early childhood. Archives of Disease in Childhood, 50, 782.
Von Berger, L., Henricks, J., Raptis, S.et al. 1976. Gastrin concentration in plasma of the neonate at birth and after the first feeding. Pediatrics 58, 264.
Walsh, J. H., Grossman, M. J. 1975. Gastrin. N. Eng. J. Med. 292, 1324.
Werlin, S. L., Grand, R. J., Drum, D. E. 1978. Congenital hypertrophic pyloric stenosis: the role of gastrin re-evaluated. Pediatrics 61, 883.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
McKiernan, J., Johnston, D.I. A re-examination of circulating gastrin and secretin levels in the human newborn. I.J.M.S. 150, 33–37 (1981). https://doi.org/10.1007/BF02938192
Issue Date:
DOI: https://doi.org/10.1007/BF02938192