Summary
AN investigation into the effects of Gliclazide, a second generation oral hypoglycaemic agent is reported. Triglyceride levels were significantly reduced but this appeared to be a function of the hypoglycaemic effect of the drug rather than a direct effect. No significant change was found in high density lipoprotein or low density lipoprotein cholesterol.
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Abraham, E. C., Huff, T. A., Cope, N. D., Wilson, J. B., Brausome, E. D., Huisan, T. H. J. (1978). Determination of the Glycosylated Haemoglobins (HSA) with a new Micro Column Method. Diabetes, 27, 931–937.
Agogardo, P., Bittolo Bon, G., Gazzolato, G., Quinci, G. B., Belussi, F. (1979). Plasma Levels of Apolipoprotein A and Apolipoprotein B in human Athersclerosis. Lancet i, 901–903.
Berber, M. J. and Tomkin, G. H. (1982). The effect of Gliclazide in Diabetes: A Comparison with Tolbutamide. lr. J. Med. Sci., 151, No. 2, 46–49.
Carlson, L A., Bottiger, L. E., Ahfeldt, P. E. (1979). Risk Factors for Myocardial Infarction in the Stockholm Prospective Study. A 14th year follow-up on the role of plasma triglycerides and cholesterol. Acta. Med. Scand., 206, (5), 351–360.
Desnoyers, P. (1980). Haemobiological Properties of Gliclazide—A General Review of the Effects on Platelet Behaviour — Microangiopathy and Gliclazide — Proceedings of an International Symposium, Bali. Development International Servier.
Forsham, P. H. (1980). Epidemiology and Pathogenesis of Vascular Complications in Diabetes and their Prevention. Microangiopathy and Gliclazide—Proceeding of an International Symposium, Bali. Development International Servier.
Friedwald, W. T., Levy, P. I., Fredrickson, D. S. 1972. (1972). Estimation of Low Density Lipoprotein Cholesterol in Plasma without the use of the Preparative Ultracentrifuge. Clin. Chem. 18, 499–502.
Goldberg, R. B. (1981). Lipid Disorders in Diabetes. Diabetes Care, 4, 561–572.
Gordon, T., Castelli, W. P., Hjortland, M. C., Kannel, W. B. and Drawber, T. R. (1977). Diabetes, Blood Lipids and the role of Obesity in Coronary Heart Disease Risk for Women. The Framingham Study. Ann. Intern. Med. 87, 393–397.
Hadden, D. R., Montgomery, D. A. D., Skelly, R. J., Trimble, E. R., Weaver, J. A. A., Wilson, E. A., Buchanan, K. D. (1975). Maturity Onset Diabetes Mellitus—Response to Intensive Dietary Management. Br. Med. J. 2, 276–278.
Kennedy, L., Walshe, K., Hadden, D. R., Weaver, J. A., Buchanan, K. D. (1982). The Effects of Intensive Dietary Therapy on Serum HDLC in Patients with Type II NIDDM: A Prospective Study. Diabetalogia, 23, 24–27.
Mancini, G., Carbonara, A. O., Heremans, J. F. (1965). Immunochemical Quantitation of Antigens by Single Radial Immunodiffusion. Immunochemistry 2, 235–354.
Regnault, A. F. (1980). Gliclazide in the Treatment of Diabetic Retinaopathy. Microangiopathy and Gliclazide. Proceedings of International Symposium, Bali. Development International Servier.
Röschlau, P. (1974). Enzymatiche Bestimmung Germant—Cholesterins in Serum. Z. Klin. Chem. Klin. Biochem. 12 (9), 403–407.
Sthle, B. W., Koehler, D. F., Azar, M. M. (1978). Enzymatic Determination of Cholesterol in Serum Proteins Separated by Electrophoresis. Clin. Chem. 24, 1116–1120.
Wahlefeld, A. W. (1974). Triglyceride Determination after Enzymatic Analysis. Ed. Bergmeyer, H. H. Methods of Enzymatic Analysis. 2nd Eng. Ed. Academic Press Inc., New York and London, 1831–1847.
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Delargy, M., McGovern, M., Johnson, A. et al. Gliclazide: The effects on lipids in type II diabetes. I.J.M.S. 154, 102–105 (1985). https://doi.org/10.1007/BF02937225
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DOI: https://doi.org/10.1007/BF02937225