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Regulation of hemopoietic cell development by interleukins 4, 5 and 6

  • Hematopoiesis, Symposium
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References

  1. McNiece, I.K.; Stewart, F.M.; Deacon, D.M.; Quesenberry, P.J.: Synergistic interactions between hematopoietic growth factors as detected by in vitro mouse bone marrow colony formation. Exp. Hematol.16: 383–388 (1988).

    PubMed  CAS  Google Scholar 

  2. Paquette, R.L.; Paquette, J.Z.; Yang, Y.; Clark, S.C.; Koeffler, H.P.: Recombinant gibbon interleukin-3 acts synergistically with recombinant human G-CSF and GM-CSF in vitro. Blood71: 1596–1600 (1988).

    PubMed  CAS  Google Scholar 

  3. Pelus, L.M.; Ottmann, O.G.; Nocka, K.H.: Synergistic inhibition of human marrow granulocyte-macrophage progenitor cells by prostaglandin E and recombinant interferon-α,-β, and-γ and an effect mediated by tumor necrosis factor. J. Immun.140: 479–484 (1988).

    PubMed  CAS  Google Scholar 

  4. Ottman, O.G.; Pelus, L.M.: Differential proliferative effects of transforming growth factor-β on human hematopoietic progenitor cells. J. Immun.140: 2661–2665 (1988).

    Google Scholar 

  5. Sugarman, B.J.; Aggarwal, B.B.; Hass, P.E.; Figari, I.S.; Palladino, M.A.; Shepard, M.H.: Recombinant human tumor necrosis factor-α: effects on the proliferation of normal and transformed cells in vitro. Science230: 943–945 (1985).

    Article  PubMed  CAS  Google Scholar 

  6. Warren, D.J.; Moore, M.A.S.: Synergism among interleukin 1, interleukin 3, and interleukin 5 in the production of eosinophils from primitive hemopoietic stem cells. J. Immun.140: 94–99 (1988).

    PubMed  CAS  Google Scholar 

  7. Mochizuki, D.Y.; Eisenman, J.R.; Conlon, P.J.; Larsen, A.D.; Tushinski, R.J.: Interleukin 1 regulates hematopoietic activity, a role previously ascribed to hemopoietin 1. Proc. natn. Acad. Sci. USA84: 5267–5271 (1987).

    Article  CAS  Google Scholar 

  8. O’Garra, A.; Umland, S.; France, T. De; Christiansen, J.: B-cell factors are pleiotropic. Immunol. Today9: 45–54 (1988).

    Article  PubMed  CAS  Google Scholar 

  9. Paul, W.E.; Ohara, J.: B-cell stimulatory factor 1/interleukin 4. Annu. Rev. Immunol.5: 429–459 (1987).

    PubMed  CAS  Google Scholar 

  10. Yokota, T.; Arai, N.; Vries, J. de; Spits, J.; Banchereau, J.; Zlotnik, A.; Rennick, D.; Howard, M.; Takebe, Y.; Miyatake, S.; Lee, F.; Arai, K.: Molecular biology of interleukin 4 and interleukin 5 genes and biology of their products that stimulate B cells, T cells and hemopoietic cells. Immunol. Rev.102: 137–187 (1988).

    Article  PubMed  CAS  Google Scholar 

  11. Coffman, R.L.; Seymour, B.W.P.; Lebman, D.A.; Hiraki, D.D.; Christiansen, J.A.; Shrader, B.; Cherwinski, H.M.; Savelkoul, H.F.J.; Finkelman, F.D.; Bond, M.W.; Mosmann, T.R.: The role of helper T cell products in mouse B cell differentiation and isotype regulation. Immunol. Rev.102: 5–28 (1988).

    Article  PubMed  CAS  Google Scholar 

  12. Marx, J.L.: Orphan interferon finds a new home. Science239: 25–26 (1988).

    Article  PubMed  CAS  Google Scholar 

  13. Smith, C.A.; Rennick, D.M.: Characterization of a murine lymphokine distinct from interleukin 2 and interleukin 3 (IL-3) possessing a T-cell growth factor activity and a mast-cell growth factor activity that synergizes with IL-3. Proc. natn. Acad. Sci. USA83: 1857–1861 (1986).

    Article  CAS  Google Scholar 

  14. Mosmann, T.R.; Bond, M.W.; Coffman, R.L.; Ohara, J.; Paul, W.E.: T cell and mast cell lines respond to B cell stimulatory factor-1. Proc. natn. Acad. Sci. USA83: 5654–5658 (1986).

    Article  CAS  Google Scholar 

  15. Rennick, D.; Yang, G.; Muller-Sieburg, C.; Smith, C.; Arai, N.; Takabe, Y.; Gemmell, L.: Interleukin 4 (B-cell stimulatory factor 1) can enhance or antagonize the factor dependent growth of hemopoietic progenitor cells. Proc. natn. Acad. Sci. USA84: 6889–6893 (1987).

    Article  CAS  Google Scholar 

  16. Peschel, C.; Paul, W.E.; Ohara, J.; Green, I.: Effects of B cell stimulatory factor-1/interleukin 4 on hematopoietic progenitor cells. Blood70: 254–263 (1987).

    PubMed  CAS  Google Scholar 

  17. Broxmeyer, H.E.; Lu, L.; Cooper, S.; Tushinski, R.; Mochizuki, D.; Rubin, B.Y.; Gillis, S.; Williams, D.E.: Snyergistic effects of purified recombinant human and murine B cell stimulatory factor-1/IL-4 on colony formation in vitro by hematopoietic progenitor cells: multiple actions. J. Immun. (in press).

  18. Rennick, D.; Jackson, J.; Yang, G.; Lee, F.; Hudak, S.: IL-6 interacts with IL-4 and with various CSFs to selectively augment the growth of distinct hemopoietic progenitor cells (submitted).

  19. Hamaguchi, Y.; Kanakura, Y.; Fujita, J.; Takeda, S.; Nakano, T.; Tarui, S.; Honjo, T.; Kitamura, Y.: Interleukin 4 as an essential factor for in vitro clonal growth of murine connective tissue-type mast cells. J. exp. Med.165: 268–273 (1987).

    Article  PubMed  CAS  Google Scholar 

  20. Saito, H.; Hatake, K.; Dvorak, A.M.; Leiferman, K.M.; Donnenberg, A.D.; Arai, N.; Ishizaka, K.; Ishizaka, T.: Selective differentiation and proliferation of hematopoietic cells induced by recombinant human interleukins. Proc. natn. Acad. Sci. USA85: 2288–2292 (1988).

    Article  CAS  Google Scholar 

  21. Defrance, T.; Vanbervliet, B.; Aubry, J.P.; Banchereau, J.: Interleukin-4 inhibits the proliferation but not the differentiation of activated human B cells in response to interleukin-2. J. exp. Med. (in press).

  22. Spits, H.; Yssel, H.; Paliard, X.; Kastelein, R.; Figdor, C.; Vries, J.E. de: IL-4 inhibits IL-2-mediated induction of human lymphokine-activated killer cells, but not the generation of antigen-specific cytotoxic T lymphocytes in mixed leukocyte cultures. J. Immun.141: 29–36 (1988).

    PubMed  CAS  Google Scholar 

  23. Roberts, A.B.; Anzano, M.A.; Wakefield, L.M.; Roche, N.S.; Stern, D.F.; Sporn, M.B.: Type β transforming growth factor: a bifunctional regulator of cellular growth. Proc. natn. Acad. Sci. USA82: 119–123 (1985).

    Article  CAS  Google Scholar 

  24. Velde, A.A. Te; Klomp, J.P.G.; Yard, B.A.; Vries, J.E. De; Figdor, C.G.: Modulation of phenotypic and functional properties of human peripheral blood monocytes by IL-4. J. Immun.140: 1548–1554 (1988).

    Google Scholar 

  25. Stuart, P.M.; Zlotnik, A.; Woodward, J.G.: Induction of class I and class II MHC antigen expression by interleukin 4 (B cell stimulatory factor 1) on murine bone marrow-derived macrophages. J. Immun.140: 1542–1547 (1988).

    PubMed  CAS  Google Scholar 

  26. Crawford, R.M.; Finbloom, D.S.; Ohara, J.; Paul, W.E.; Meltzer, M.S.: B cell stimulatory factor-1 (interleukin 4) activates macrophages for increased tumoricidal activity and expression of Ia antigens. J. Immun.139: 135–141 (1987).

    PubMed  CAS  Google Scholar 

  27. Zlotnik, A.; Fischer, M.; Roehm, N.; Zipori, D.: Evidence for effects of interleukin 4 (B cell stimulatory factor 1) on macrophages: enhancement of antigen presenting ability of bone marrow-derived macrophages. J. Immun.138: 4275–4279 (1987).

    PubMed  CAS  Google Scholar 

  28. McInnes, A.; Rennick, D.M.: Interleukin 4 induces cultured monocytes/macrophages to form giant multinucleated cells. J. exp. Med.167: 598–611 (1988).

    Article  PubMed  CAS  Google Scholar 

  29. Sideras, P.; Noma, T.; Honjo, T.: Structure and function of interleukin 4 and 5. Immunol. Rev.102: 189–212 (1988).

    Article  PubMed  CAS  Google Scholar 

  30. Sanderson, C.J.; Warren, D.J.; Strath, M.: Identification of a lymphokine that stimulates eosinophil differentiation in vitro. Its relationship to Il-3, and functional properties of eosinophils produced in cultures. J. exp. Med.162: 60–74 (1985).

    Article  PubMed  CAS  Google Scholar 

  31. Lopez, A.F.; Begley, C.G.; Williamson, D.J.; Warren, D.J.; Vadas, M.A.; Sanderson, C.J.: Murine eosinophil differentiation factor. An eosinophil-specific colony stimulating factor with activity for human cells. J. exp. Med.163: 1085–1099 (1986).

    Article  PubMed  CAS  Google Scholar 

  32. Lopez, A.F.; Sanderson, C.J.; Gamble, J.R.; Campbell, H.D.; Young, I.G.; Vadas, M.A.: Recombinant human interleukin 5 is a selective activator of human eosinophil function. J. exp. Med.167: 219–224 (1988).

    Article  PubMed  CAS  Google Scholar 

  33. Gleich, G.J.; Adolphson, C.R.: The eosinophilic leukocyte: structure and function. Adv. Immunol.39: 177–253 (1986).

    Article  PubMed  CAS  Google Scholar 

  34. Coffman, R.L.; Hudak, S.; Seymour, B.W.P.; Jackson, J.; Rennick, D.: Anti-IL-5 antibody inhibits helminth induced eosinophilia in vivo (submitted).

  35. Wong, G.G.; Witek-Giannotti, J.S.; Temple, P.A.; Driz, R.; Ferenz, C.; Hewick, R.M.; Clark, S.C.; Ikebuchi, K.; Ogawa, M.: Stimulation of murine hemopoietic colony formation by human IL-6. J. Immun.140: 3040–3044 (1988).

    PubMed  CAS  Google Scholar 

  36. Chiu, C.; Moulds, C.; Coffman, R.; Rennick, D.; Lee, F.: Multiple biological activities are expressed by a mouse interleukin-6 cDNA clone isolated from bone marrow stromal cells. Proc. natn. Acad. Sci. USA85: 7099–7103 (1988).

    Article  CAS  Google Scholar 

  37. Ikebuchi, K.; Wong, G.G.; Clark, S.C.; Ihle, J.N.; Hirai, Y.; Ogawa, M.: Interleukin 6 enhancement of interleukin 3-dependent proliferation of multipotential hemopoietic progenitors. Proc. natn. Acad. Sci. USA84: 9035–9039 (1987).

    Article  CAS  Google Scholar 

  38. Leary, D.G.; Ikebuchi, K.; Hirai, Y.; Wong, G.G.; Yang, Y.; Clark, S.C.; Ogawa, M.: Synergism between interleukin-6 and interleukin-3 in supporting proliferation of human hematopoietic stem cells: comparison with interleukin-1α. Blood71: 1759–1763 (1988).

    PubMed  CAS  Google Scholar 

  39. Bradley, T.R.; Hodgson, G.S.: Detection of primitive macrophage progenitor cells in mouse bone marrow. Blood54: 1446–1450 (1979).

    PubMed  CAS  Google Scholar 

  40. Zipori, D.: Cultured stromal cell lines from hemopoietic tissue; in Blood cell formation: the role of hemopoietic microenvironment (Dekker, New York 1987).

    Google Scholar 

  41. Rennick, D.; Yang, G.; Gemmell, L.; Lee, F.: Control of hemopoiesis by a bone marrow stromal cell clone: lipopolysaccharide- and interleukin-1-inducible production of colony-stimulating factors. Blood69: 682–691 (1987).

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Immunology, DNAX Research Institute of Molecular and Cellular Biology, 94304, Palo Alto, CA, (USA)

    Donna Rennick, Susan Hudak, Gloria Yang & John Jackson

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  1. Donna Rennick
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  2. Susan Hudak
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  3. Gloria Yang
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  4. John Jackson
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Rennick, D., Hudak, S., Yang, G. et al. Regulation of hemopoietic cell development by interleukins 4, 5 and 6. Immunol Res 8, 215–225 (1989). https://doi.org/10.1007/BF02918146

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