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Studies on the antibodies to human herpesvirus type 6 among Hungarian patients with asymptomatic HIV infection

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Pathology & Oncology Research

Abstract

The occurrence and the possible role in promoting HIV infection by human herpesvirus type 6 (HHV-6) have not yet been revealed in Hungary. In different groups of patients, serum titre of IgM and IgG antibodies, as well as avidity of IgG were quantitated by indirect immunofluorescence and an enzyme-linked immunosorbent assay, using isolate U1102 of HHV-6 variant A as antigen. In 60% of HIV-seronegative adult controls, high avidity IgG antibodies were found in low titre suggesting childhood infection. In HIV-seronegative persons with high risk behaviour for HIV-infection, both IgM and low avidity IgG were frequently found in higher titre, representing either primary or frequent reinfections, or reactivation of latent HHV-6. In asymptomatic HIV-seropositive patients, high titre of high avidity IgG antibodies was predominant, proving virus infection in the near past. These results indicate the contribution of HHV-6 to immunosuppression prior to AIDS, predisposing the organism to HIV infection.

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Authors and Affiliations

  1. Institute of Microbiology, Semmelweis University of Medicine, Budapest, Hungary

    Csaba László MarÓdi, Anna CsiszÁr, Beatriz SIerra-Vazquez & Joseph OngrÁdi

  2. Institute of Microbiology, University of Ferrara, Ferrara, Italy

    Dario DI Luca

  3. National Institute of Dermato-Venereology, Mária utca 41., 1085, Budapest, Hungary

    Éva BarabÁs & Károly Nagy

Authors
  1. Csaba László MarÓdi
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  2. Anna CsiszÁr
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  3. Beatriz SIerra-Vazquez
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  4. Dario DI Luca
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  5. Éva BarabÁs
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  6. Károly Nagy
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  7. Joseph OngrÁdi
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Correspondence to Joseph OngrÁdi.

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MarÓdi, C.L., CsiszÁr, A., SIerra-Vazquez, B. et al. Studies on the antibodies to human herpesvirus type 6 among Hungarian patients with asymptomatic HIV infection. Pathol. Oncol. Res. 4, 56–61 (1998). https://doi.org/10.1007/BF02904698

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  • DOI: https://doi.org/10.1007/BF02904698

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