Summary
Weanling rats and mice were fed on a low-iron diet. By the end of the 4th week, the rats were sacrificed and tested for state 01 immunity, and the mice were infected with S. typhimurium. Rate of peripheral blood lymphocytic transformation, total serum complement activity (CH50) and splenic tissue cAMP levels in the iron-deficient rats were significantly decreased as compared with those of the controls. There was no significant difference in the levels of serum hemolysin (HC50) and serum lysozyme between iron-deficient and control rats. Gross histological changes could be observed in the spleen of the iron-deficient rats, but no change was seen in the thymus. After intraperitoneal injection with S. typhimurium, the mortality of iron-deficient mice was significantly increased as compared with that of the controls.
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References
WHO. Control of nutritional anaemia with special reference to iron deficiency. WHO Tech Rep Ser 1975; 580.
Cook JD, et al. Evaluation of the iron status of a population. Blood 1976; 48: 449–55.
16. 1982; (4): 30–4.
Beisel WR. Single nutrients and immunity. Am J Clin Nutr 1982; 35 (2 Suppl): 417–68.
Report of the American Institute of Nutrition Ad Hoc Committee on Standards for Nutritional Studies. J Nutr 1977; 107: 1340–8.
1979; 14: 443–6.
1. 1982.
Baggs RB, et al. Nutritional iron deficiency as a determinant of host resistance in the rat. J Nutr 1973; 103: 1554–60.
Kuvibidila SR, et al. Effects of iron deficiency anemia on delayed cutaneous hypersensitivity in mice. Am J Clin Nutr 1981; 34: 2635–40.
Kuvibidila SR, et al. Impairment of blastogenic response of splenic lymphocytes from iron-deficient mice: in vivo repletion. Am J Clin Nutr 1983; 37: 15–25.
Krantman HJ, et al. Immune function in pure iron deficiency. Am J Dis Child 1982; 136: 840–4.
Jagadeesan V, et al. Complement system in iron deficiency anemia. Experientia 1983; 39: 146.
Kokoshis PL, et al. Serum lysozyme: an index of macrophage function. J Reticuloendothel Soc 1979; 25: 85–99.
Kook AI, et al. The control exerted by thymic hormone (THF) on cellular cA-MP levels and immune reactivity of spleen cells in the MLC assay. J Immunol 1975; 115: 8–14.
Rothenbacher H, et al. Target organ pathology in iron deficient suckling rats. J Nutr 1980; 110: 1648–54.
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Li-qun, T., Qing-hua, Z. Experimental study on effects of iron deficiency anemia on immune function. Journal of Tongji Medical University 7, 252–257 (1987). https://doi.org/10.1007/BF02888453
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DOI: https://doi.org/10.1007/BF02888453