Summary
Anti-murine IL-1α, IL-6 antibodies were intra-peritoneally injected to the lupus-like NZB/W F1 mice of 4 months with the dosage of 10 μg per day for three days and then per month for three months. The mice were killed at the age of 11 months. The results showed that the treatment of the dosage could not absolutely prevent lupus nephritis; it could alleviate proteinuria, obviously reduce the levels of serum IL-1α and inhibit the secretion of IL-1α by celiac macrophage. As to the level of IL-6 and TNF-α no significant change was observed.
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The project is surported by the National Science Foundation of China (No. 39270637)
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Wenli, L., Hanying, S., Jingfang, S. et al. Immunoregulation of lupus-like NZB/W F1 mice by antimurine IL-1α, IL-6 antibodies. Journal of Tongji Medical University 16, 209–211 (1996). https://doi.org/10.1007/BF02888108
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DOI: https://doi.org/10.1007/BF02888108