Summary
This investigation revealed that the contents of A II and NE in plasma, heart and aorta and E content in plasma were significantly increased in SHR at the age of 12th week. At the same time the systolic blood pressure of SHR was much higher than that of the age-matched WKY. The intracerebroventricular administration of 6-OHDA in SHR at the age of 8th week not only prevented the development of hypertension, but also reduced the contents of NE and E in the brain regions, heart, aorta and plasma. Simultaneously A II content in heart, aorta and plasma was decreased. These results suggested that: 1, the renin-angiotensin system and peripheral sympatho-adrenal system are overactive in SHR, 2. the overactivity of peripheral sympatho-adrenal system is dependent on the central catecholaminergic neurons, and 3. the action of sympatho-adrenal system is partly responsible for the increase of A II content in plasma, heart and aorta in SHR.
Similar content being viewed by others
References
Schelling P Get al. The brain renin-angiotensin system: biochemistry, localization and functional aspects. In: Advances in experimental Medicine: A Centenary tribute to Claude Bernard, edited by H. Paravez and P. Paravez. Ameterdam: Elseuier/North Holland, 1980; p243–288.
Bohr D F. Angiotensin on vascular muscle. In: Hand book of Experimental Pharmacology, edited by I. H. Page and F. M. Bumpus. Heidelberg, FRG: Springer-Verlag, 1974; p 424–440.
Huang M Y,et al. Method for determination of plasma catecholamine. Acta. Third Milit. Med College, 1985;7(3): 245–250 (in Chinese)
Subha Senet al. Renin in rats with spontaneous hypertension. Circ Res 1972;31:876–880
Thoren P, Efferent renal nerve traffic in the spontaneously hypertensive rat. Clin & Exp Hyperten, 1987;A9(suppl 7):259–279
Chun H P. Plasma adrenaline and noradrenaline concentrations of the spontaneously hypertensive rat. Jpn Heart J, 1981; 22(6): 987–995
Esler Met al. Assessment of human sympathetic nervous system activity from measurements of norepinephrine turnover Hypertension. 1988;11 (1):3–20
Alfonse J. T., and Gerald M. W., The spontaneously hypertensive rat. Hypertension Research: Methods and Models. Marcel Dekker. New York 1982;p427–446
Tadashi, I.,et al. Intracellular action of renin, angiotensin production and release. J. Hypertens. 1986;4(suppl, 4):s11-s16
Nakamura, M., β-adrenoceptor-mediated release of angiotensinI from mesenteric arteries. Am. J. Physiol. 1986;250:H144-H148
Author information
Authors and Affiliations
Additional information
this project was supported by grant NO. 75-62-02-05 from the National Committee of Science and Technique.
Rights and permissions
About this article
Cite this article
Jun, D., Hu, D., Zhen-ying, W. et al. Effect of intracerebroventricular injection of 6-hydroxydopamine on the peripheral catecholamine and angiotensin II in SHR. Journal of Tongji Medical University 13, 202–205 (1993). https://doi.org/10.1007/BF02888009
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02888009