Skip to main content
SpringerLink
Log in

DNA damage effects of hydroxyapatite ultrofine powder on W-256 sarcoma cells and lymphocytes in rats

  • Published:
Current Medical Science Aims and scope Submit manuscript

Summary

To explore the anticancer mechanism and DNA damages of hydroxyapatite ultrofine powder (HAUFP) on lymphocytes of rats, DNA damages in W-256 sarcoma cells and lymphocytes of rats were measured by single cell gel electrophoresis (SCGE). The results showed that HAUFP damaged DNA of W-256 sarcoma cells obviously but only cause slight damage of DNA of lymphocytes in rats. It is suggested that HAUFP selectively damaged DNA of tumor cells with only mild damage of lymphocyte DNA. HAUFP has powerful anticancer effect and little genetic toxicity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. 1996, 18(1):5

  2. Ostling O, Johanson K J. Microelectrophoretic study of radiation-induced DNA damages in individual mamalian cell. Biophys Res Common, 1984, 123:291

    Article  CAS  Google Scholar 

  3. Singh N P, Mccoy M T, Tice R Ret al. A simple technique of quantitation of low level of DNA damage in individual cells. Exp Cell Res, 1988, 175:184

    Article  CAS  PubMed  Google Scholar 

  4. Gedik C M, Ewen S W B, Collins A R. Singlecell gel electrophoresis applied to the analysis of UV-C damage and its repair in human cells. Int J Radiat Biol, 1992, 60(3):313

    Article  Google Scholar 

  5. Oliver P L, Banath J P, Durand R E. Heterogeneity in radiation-induced DNA damage and repair in.tumor and normal cells measured using the ‘comet” assay. Radiat Res, 1990, 122:86

    Article  ADS  Google Scholar 

  6. 1988.11.

  7. 1990.16.

  8. Betti C, Davini T J, Barale R. Liquid-holding experiments On Go human lymphocytes exposed to methlmercury chloride. Mutation Res, 1993 (6), 301:267

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of General Surgery, Xiehe Hospital, Tongji Medical University, 430022, Wuhan

    Xia Qinghua (Doctor in Charge), Chen Daoda, Zhang Jianpin, Tian Yuan & Zhang Jinghui

  2. Departmnet of General Surgery, Puqi People’s Hospital, 437300, Puqi

    Hu Panlin

Authors
  1. Xia Qinghua
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hu Panlin
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Chen Daoda
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Zhang Jianpin
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Tian Yuan
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Zhang Jinghui
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

This project was supported by a grant from National Natural Science Foundation of China (Serial No. 39770225).

Rights and permissions

Reprints and permissions

About this article

Cite this article

Qinghua, X., Panlin, H., Daoda, C. et al. DNA damage effects of hydroxyapatite ultrofine powder on W-256 sarcoma cells and lymphocytes in rats. Current Medical Science 19, 215–218 (1999). https://doi.org/10.1007/BF02887738

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02887738

Key words

Search

Navigation