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Behavior of prealbumin in the acute phase of polymyalgia rheumatica treated with 6-methylprednisolone

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Research in Clinic and Laboratory

Summary

Serum levels of prealbumin, fibronectin, fibrinogen, α1-acid glycoprotein, C-reactive protein, immunoglobulins, and white blood cell count were prospectively studied in 33 patients affected by polymyalgia rheumatica during the first 45 days of treatment with 6-methylprednisolone. Almost all parameters considered, except for fibronectin and IgM, settled within the normal range fairly quickly, while prealbumin showed a specular course compared with the other reactants. This behavior reflected the improvement of clinical symptoms registered in all patients after steroid treatment. Finally, the genesis of the low baseline prealbumin levels found in polymyalgia rheumatica/giant cell arteritis and their behavior during treatment are discussed.

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Authors and Affiliations

  1. Servizio di Reumatologia Istituto di Patologia Medica I, Università degli Studi di Pisa, Spedali Riuniti di S. Chiara, Via Roma 2, 56100, Pisa, Italia

    Luca Puccetti, Paola Barbieri, Daniela Melchiorre, Mauro Zuccotti, Gabriella Petrini, Giorgio Marotta, Elisabetta Remorini & Maria Laura Ciompi

  2. Laboratorio Analisi Cliniche, Spedali Riuniti di S. Chiara, USL 12, Pisa

    Amalia Lucchetti

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  1. Luca Puccetti
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  2. Amalia Lucchetti
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Puccetti, L., Lucchetti, A., Barbieri, P. et al. Behavior of prealbumin in the acute phase of polymyalgia rheumatica treated with 6-methylprednisolone. Res. Clin. Lab. 19, 251–258 (1989). https://doi.org/10.1007/BF02871814

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  • DOI: https://doi.org/10.1007/BF02871814

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