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Preparation of Indapamide slow-release pellets

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Abstract

During the process of developing a slow-release formulation of indapamide, researchers created a drug-containing pellet coated with Eudragit® RS100 (Rohm GMbH & Co. KG, Darmstadt, Germany) to control the rate at which the drug was released. The two main variables were the agglomerants used in the pellet preparation and the amount of Eudragit RS100 used to coat them. The optimal outcome was indicated by the greatest number of drug-containing pellets recovered through an 18-to 24-mesh sieve and a satisfactory 24-hour release curve. The kinetics of dissolution fit the Higuchi kinetics model. Stability tests of the drug pellets showed no notable changes in the rate of drug release, related substances (mean byproducts or impurities from interactions or decompositions), and drug content.

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Authors and Affiliations

  1. School of Pharmacy, Shanghai JiaoTong University, 1954 Huashan Road, 200030, Shanghai, P.R. China

    Wei Jia PhD, Mingfeng Qiu PhD & Xia Sun MS

  2. College of Pharmaceutical Science and Technology, Tianjin University, Tianjin, China

    Yungping Qiu MS & Mingming Su MS

Authors
  1. Wei Jia PhD
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  2. Mingfeng Qiu PhD
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  3. Xia Sun MS
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  4. Yungping Qiu MS
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  5. Mingming Su MS
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Jia, W., Qiu, M., Sun, X. et al. Preparation of Indapamide slow-release pellets. Adv Therapy 21, 238–246 (2004). https://doi.org/10.1007/BF02850156

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  • DOI: https://doi.org/10.1007/BF02850156

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