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Does allopurinol reduce pain of chronic pancreatitis?

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Summary

Conclusion

A dosage of 300 mg/d of allopurinol was not effective in reducing pain or improving activities of daily living in chronic pancreatitis.

Background

Allopurinol prevents the generation of oxygen-derived free radicals by inhibiting xanthine oxidase. The purpose of this study was to determine whether allopurinol is effective in reducing pain of chronic pancreatitis.

Methods

Thirteen patients with chronic pancreatitis who were experiencing abdominal pain requiring medication at least three times each week entered a randomized, double-blind, two-period crossover clinical trial. Patients evaluated their pain daily using a categorical pain intensity scale, numeric pain intensity scale, and a visual analog scale, and weekly completed a McGill Pain Questionnaire and activities of daily living (ADL) questionnaire.

Results

The mean baseline score of pain was approx 50% of most severe pain in all scoring systems. There was no significant decrease in pain associated with allopurinol compared to the placebo (p=0.24–0.75). In addition, there was no benefit in terms of ADL score associated with allopurinol compared with placebo (p=0.32). Mean uric acid level was decreased by 1.15 mg/dL while patients were taking allopurinol, compared to when they were taking placebo (p=0.007).

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References

  1. Karanjia ND, Widdison AL, Leung F, Alvarez C, Lutrin J, Reber HA. Compartment syndrome in experimental chronic obstructive pancreatitis: effect of decompression on the main pancreatic duct.Br J Surg 1994; 81: 259–264.

    Article  PubMed  CAS  Google Scholar 

  2. Sanfey H, Sarr MG, Buckley GB, Cameron JL. Oxygenderived free radicals in acute pancreatitis: a review.Acta Physiol Scand 1986; 548: 109–118.

    CAS  Google Scholar 

  3. Melzack R: The short-form McGill Pain Questionnaire.Pain 1987; 30: 191–197.

    Article  PubMed  CAS  Google Scholar 

  4. Kerns RD, Turk DC, Rudy TE. The West Haven-Yale Multidimensional Pain Inventory (WHYMPI).Pain 1985; 23: 345–356.

    Article  PubMed  CAS  Google Scholar 

  5. Jones B, Kenward DG.Design and Analysis of Cross-Over Trials. Chapman and Hall, London, 1989, pp. 60–67.

    Google Scholar 

  6. Zenz M, Strumpf M, Tryba M. Long-term oral opioid therapy in patients with chronic nonmalignant pain.J Pain Symptom Manage 1992; 7: 69–77.

    Article  PubMed  CAS  Google Scholar 

  7. Patel AG, Toyama MT, Alvarez C, Nguyen TN, Reber PU, Ashley SW, Reber HA. Pancreatic interstitial pH in human and feline chronic pancreatitis.Gastroenterology 1995; 109: 1639–1645.

    Article  PubMed  CAS  Google Scholar 

  8. Ebbehoj N, Borly L, Bulow J, Rasmussen SG, Madsen P. Evaluation of pancreatic tissue fluid pressure and pain in chronic pancreatitis.Scand J Gastroenterol 1990; 25: 462–466.

    Article  PubMed  CAS  Google Scholar 

  9. Ebbehoj N, Borly L, Bulow J, Rasmussen SG, Madsen P, Matzen P, Owre A: Pancreatic tissue fluid pressure in chronic pancreatitis.Scand J Gastroenterol 1990; 25: 1046–1051.

    Article  PubMed  CAS  Google Scholar 

  10. Ebbehoj N, Borly N, Madsen P, Matzen P. Pancreatic tissue fluid pressure during drainage operations for chronic pancreatitis.Scan J Gastroenterol 1990; 25: 1041–1045.

    Article  CAS  Google Scholar 

  11. Freeman BA, Crapo JD. Biology of disease: free radicals and tissue injury.Lab Invest 1982; 47: 412–426.

    PubMed  CAS  Google Scholar 

  12. Basso D, Panozzo MP, Fabris C, del Favero G, Meggiato T, Fogar P, Meani A, Faggian D, Plebani M, Burlina A, Naccarato R. Oxygen derived free radicals in patients with chronic pancreatic and other digestive diseases.J Clin Pathol 1990; 43: 403–405.

    Article  PubMed  CAS  Google Scholar 

  13. Rose P, Fraine E, Hunt LP, Acheson DWK, Braganza JM. Dietary antioxidants and chronic pancreatitis.Human Nutrition: Clin Nutrition 1986; 40C: 151–164.

    Google Scholar 

  14. Uden S, Bilton D, Nathan L, Hunt LP, Mains C, Braganza JM. Antioxidant therapy for recurrent pancreatitis: placebo-controlled trial.Aliment Pharmacol Therap 1990; 4: 357–371.

    Article  CAS  Google Scholar 

  15. Braganza JM, Jeffrey IJM, Foster J, McCloy RF. Recalcitrant pancreatitis: eventual control by antioxidants.Pancreas 1987; 2: 489–494.

    Article  PubMed  CAS  Google Scholar 

  16. Salim AS. Role of oxygen-derived free radical scavengers in the treatment of recurrent pain produced by chronic pancreatitis.Arch Surg 1991; 126: 1109–1114.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Center for Pancreatic Disease, Brigham and Women's Hospital, Harvard Medical School, 02115, Boston, MA

    P. A. Banks (Director), M. Hughes, M. Ferrante, E. C. Noordhoek, V. Ramagopal & A. Slivka

Authors
  1. P. A. Banks
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  2. M. Hughes
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  3. M. Ferrante
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  4. E. C. Noordhoek
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  5. V. Ramagopal
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  6. A. Slivka
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Banks, P.A., Hughes, M., Ferrante, M. et al. Does allopurinol reduce pain of chronic pancreatitis?. Int J Pancreatol 22, 171–176 (1997). https://doi.org/10.1007/BF02788381

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  • DOI: https://doi.org/10.1007/BF02788381

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