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Self-reactive B cells in nonautoimmune and autoimmune mice

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Abstract

The defining feature of autoimmune disease is the presence of specific autoreactive lymphocytes. Systemic lupus erythematosus (SLE), for example, is characterized by a discrete set of antibodies directed to nuclear antigens; these include autoantibodies to DNA and snRNPs that are diagnostic for SLE. The murine model of SLE, theMRL-lpr/lpr mouse, likewise, has a similar autoantibody profile. To understand how SLE-associated autoantibodies are regulated in healthy individuals and to identify mechanisms underlying their expression in autoimmunity, we have developed a transgenic (tg) model system using multiple sets of tgs. The development of B cells bearing these tgs has been studied in B ALB/c andMRL-lpr/lpr autoimmune backgrounds, and the relative fates of anti-ssDNA and anti-dsDNA tg B cells when they are a part of a diverse as well as monoclonal B cell repertoire have been evaluated.

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  1. The Wistar Institute, Room 273, 3601 Spruce St, 19104, Philadelphia, PA

    Jan Erikson, Laura Mandik, Anh Bui, Ashlyn Eaton, Hooman Noorchashm, Kim-Anh T. Nguyen & Jessica H. Roark

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  1. Jan Erikson
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Erikson, J., Mandik, L., Bui, A. et al. Self-reactive B cells in nonautoimmune and autoimmune mice. Immunol Res 17, 49–61 (1998). https://doi.org/10.1007/BF02786430

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