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Angiotensin-converting enzyme in sarcoidosis and other pulmonary diseases: A comparison of two methods of determination

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Abstract

The authors compare two methods of determining serum angiotensin-converting enzyme (ACE) in sarcoidosis and various pulmonary diseases. The Cushman-Cheung method [3], which measures hippuric acid formed from hippuryl-histidyl-leucine, appears to be more sensitive and specific than the Depierre-Roth fluorometric assay [4], which uses histidine-leucine liberated from a phenylalanine-histidine-leucine substrate. In sarcoidosis, the first method results in 59% (n = 132) high values as compared to 36% (n = 143) with the second.

In other pulmonary diseases, the frequency of high values with the Cushman-Cheung method does not exceed 7%, while it reaches 30% in tuberculosis and nearly 20% in chronic obstructive lung disease with the Depierre-Roth method. The data obtained with the Cushman-Cheung method in sarcoidosis confirm previous studies. Measurement of the serum ACE level is a good test to confirm sarcoidosis; high levels are related to the extent of the disease.

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Authors and Affiliations

  1. Service de Pneumologie, Hôpital Avicenne, 125, Route de Stalingrad, 93009 Bobigny, and Groupe INSERM U82, UER Bichat-Beaujon, 170, Boulevard Ney, F-75877, Paris, Cedex 18, France

    D. Sandron, D. Lecossier, F. Moreau, A. Grodet, G. Basset & J. P. Battesti

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  1. D. Sandron
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  2. D. Lecossier
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  3. F. Moreau
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  4. A. Grodet
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  5. G. Basset
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  6. J. P. Battesti
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Hôpital Avicenne. Address requests for reprints to Dr. Battesti.

Groupe INSERM.

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Sandron, D., Lecossier, D., Moreau, F. et al. Angiotensin-converting enzyme in sarcoidosis and other pulmonary diseases: A comparison of two methods of determination. Lung 157, 31–38 (1979). https://doi.org/10.1007/BF02713591

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  • DOI: https://doi.org/10.1007/BF02713591

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