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Cardiovascular phenotype characterization in mice by high resolution magnetic resonance imaging

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Magma: Magnetic Resonance Materials in Physics, Biology, and Medicine Aims and scope Submit manuscript

9. Conclusion

Due to its high temporal and spatial resolution, magnetic resonance imaging meets the requirements for accurate and robust in vivo visualization of the murine cardiovascular system. As an intrinsically three-dimensional imaging technique, it allows for quantification of LV volumes without relying on geometric models. Therefore, MRI is uniquely suited for the investigation of morphologic and functional changes in models of heart failure.

The potential application of MRI in the mouse comprises visualization of cardiovascular anatomy and pathology in newborn and adult mice, detection of LV geometric and functional changes both acutely and chronically, visualization of cardiac microstructures such as cardiac valves and coronary arteries, and characterization and quantification of arteriosclerotic plaques in major murine arteries. Furthermore, MR spectroscopy applied to the mouse heart can give important information on in vivo myocardial metabolism. Thus, we feel confident that high resolution MRI may substantially contribute to the understanding of the basic mechanisms of a variety of cardiovascular diseases.

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Authors and Affiliations

  1. Medizinísche Universitätsklinik Würzburg, Josef-Schneider-Str. 2, 97080, Würzburg, Germany

    Frank Wiesmann, Charlotte Dienesch & Andrea Leupold

  2. Physikalisches Institut, Universität Würzburg, Germany

    Jan Ruff, Eberhard Rommel & Axel Haase

  3. Department of Cardiovascular Medicine, Oxford University, Oxford, UK

    Stefan Neubauer

Authors
  1. Frank Wiesmann
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  2. Jan Ruff
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  3. Charlotte Dienesch
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  4. Andrea Leupold
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  5. Eberhard Rommel
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  6. Axel Haase
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  7. Stefan Neubauer
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Correspondence to Frank Wiesmann.

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Wiesmann, F., Ruff, J., Dienesch, C. et al. Cardiovascular phenotype characterization in mice by high resolution magnetic resonance imaging. MAGMA 11, 10–15 (2000). https://doi.org/10.1007/BF02678482

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