Abstract
The proton magnetic resonance spectroscopic imaging techniques that use read gradient during acquisition produce proton spectra with high spatial and moderately high spectroscopic resolution in a reasonable time forin vivo applications. These techniques suffer mainly from the spatial and pectral distortions caused by the convolution of spectral/spatial information (chemical-shift artifacts) and from the spectral shifts caused by static magnetic field inhomogeneities. The investigators analyze the chemical-shift artifacts in the presence of nonnegligible static magnetic field inhomogeneities and propose a postdetection processing scheme to correct for such effects. Spectral artifacts caused by chemical shifts, spectral line overlapping, streak broadening, and magnetic field inhomogeneities are discussed. The postdetection data processing scheme is demonstrated on measurements of a phantom as well as a human leg.
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Brown TR, Kincaid BM, Ugurbil K (1982) NMR chemical shift imaging in the three dimensions.Proc Natl Acad Sci USA 79: 3523–3526.
Maudsley AA, Hilal SK, Perman WH, Simon HE (1983) Spatially resolved high resolution spectroscopy by “four-dimensional” NMRJ Magn Reson 51: 147–152.
Maudsley AA, Oppelt A, Ganssen A (1979) Rapid measurement of magnetic field distribution using nuclear magnetic resonance.Siemens Forschung Entwicklung,8: 326–329.
Mansfield P (1984) Spatial mapping of the chemical shift in NMR.Magn Reson Med 1: 370–386
Guilfoyle D, Mansfield P (1985) Chemical-shift imaging.Magn Reson Med 2: 479–489.
Sepponen RE, Sipponen JT, Tantu JI (1984) A method for chemical shift imaging: demonstration of bone marrow involvement with proton chemical shift imaging.J Comput Assist Tomogr 8: 585–587.
Matsui S, Sekihara K, Kohno H (1985) High-speed spatially resolved high-resolution NMR spectroscopy.J Am Chem Soc 107: 2817–2818.
Matsui S, Sekihara K, Kohno H (1986) Spatially resolved NMR spectroscopy using phase modulated spin-echo trains.J Magn Reson 67:476–490.
Cho ZH, Nalcioglu O, Park HW, Ra JB, Hilal SK (1985) Chemical-shift correction scheme using echo-time encoding technique.Magn Reson Med 2: 253–261.
Twieg DB, McKinnon GC (1986) Multiple-output chemical shift imaging (MOCSI)—a rapid method for chemical-shift imaging and localized moderate resolution NMR spectroscopy.Magn Reson Imaging 4: 118–119.
Guilfoyle DN, Blamire A, Chapman B, Ordige RJ, Mansfield P (1989) PEEP-a rapid chemical shift imaging method.Magn Reson Med 10: 282–287.
Twieg DB (1989) Multiple-output chemical shift imaging (MOCSI): a practical technique for rapid spectroscopic imaging.Magn Reson Med 12: 64–73.
Webb P, Spielman D, Macovski A (1989) A fast spectroscopic imaging method using a blipped phase encode gradient.Magn Reson Med 12: 306–315.
Haase A, Matthei D (1987) Spectroscopic FLASH imaging (SPLASH imaging).J Magn Reson 71: 550–553.
Weis J, Frolo I, Budinsky L (1989) Magnetic field distribution measurement by the modified FLASH method.Z Naturforsch 44a: 1151–1154.
Haase A (1990) Snapshot FLASH MRI: applications to T1, T2, and chemical-shift imaging.Magn Reson Med 13: 77–89.
Posse S, Tedeshi G, Risinger R, Ogg R, Le Bihan D (1995) High speed1H spectroscopic imaging in human brain by echo planar spatial-spectral encoding.Magn Reson Med 33: 34–40.
Bito Y, Hirata S, Nabeshima T, Yamamoto E (1995) Echoplanar diffusion spectroscopic imaging.Magn Reson Med 33: 69–73.
Adalsteinsson E, Irarrazobal R, Spielman DH, Macovski A (1995) Three-dimensional spectroscopic imaging with time-varying gradients.Magn Reson Med 33: 461–466.
Maudsley AA, Hilal SK (1985) Field inhomogeneity correction and data processing for spectroscopic imaging.Magn Reson Med 2: 218–233.
Manassen Y, Navon G (1985) A constant gradient experiment for chemical-shift imaging.J Magn Reson 61: 363–370.
Park HW, Cho ZH (1986) High-resolution humanin vivo spectroscopic imaging using echo-time encoding technique.Magn Reson Med 3: 448–453.
Spielman S, Webb P, Macovski D (1989) Water referencing for spectroscopic imaging.Magn Reson Med 12: 38–49.
Webb P, Spielman D, Macovski A (1992) Inhomogeneity correction forin vivo spectroscopy by high-resolution water referencing.Magn Reson Med 23: 1–11.
Ordige RJ, Cresshull ID (1986) The correction of transient B0 field shifts following the application of pulsed gradients by phase correction in the time domain.J Magn Reson 69: 151–155.
Maudsley AA, Wu Z, Meyerhoff DJ, Weiner MW (1994) Automated processing for proton spectroscopic imaging using water reference deconvolution.Magn Reson Med 31: 589–595.
Ericsson A, Weis J, Hemmingsson A, Wikström W, Sperber GO (1995) Measurement of magnetic field variations in the human brain using a 3D-FT multiple gradient echo technique.Magn Reson Med 33: 171–177.
Christoffersson JO, Olsson LE, Sjöberg S (1991) Nickel-dopped agarose gel phantoms in MR imaging.Acta Radiol 32: 426–431.
Weis J, Nilsson S, Ericsson A, Wikström M, Sperber GO, Hemmingsson A (1994) Measurement of magnetic susceptibility and MR contrast agent concentration.Magn Reson Imaging 12: 859–864.
Weis J, Budinsky L (1990) Simulation of the influence of magnetic field inhomogeneity and distortion correction in MR imaging.Magn Reson Imaging 8: 483–489.
Sekihara K, Matsui S, Kohno H (1985) NMR imaging for magnets with large nonuniformities.IEEE Trans Med Imaging MI-4(4): 193–199.
Thomsen C, Becker U, Winkler K, Christoffersen P, Jensen M, Henriksen O (1994) Quantification of liver fat using magnetic resonance spectroscopy.Magn Reson Imaging 12: 487–495.
Schick F, Eismann B, Jung WI, Bongers H, Bunse M, Lutz O (1993) Comparison of localized proton NMR signals of skeletal muscle and fat tissuein vivo: two lipid compartments in muscle.Magn Reson Med 29: 158–167.
Weis J, Görke U, Kimmich R (1996) Susceptibility, field inhomogeneity and chemical-shift corrected NMR microscopy: application to the human fingerin vivo.Magn Reson Imaging 14: 1165–1175.
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Supported by the Swedish Medical Research Council, project B-96-17x-006676-14A, and by Uppsala University are gratefully acknowledged. One of us (J.W.) is indebted to the Institute of Measurement Science, Slovak Academy of Sciences, for continuous support, VEGA Grant No. 95/5305/585,468 & 2/1207/96
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Weis, J., Ericsson, A. & Hemmingsson, A. 1H-spectroscopic imaging with read gradient during acquisition in inhomogeneous fields: analysis, measurement strategy, and data processing. MAGMA 5, 201–212 (1997). https://doi.org/10.1007/BF02594583
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DOI: https://doi.org/10.1007/BF02594583