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Outcome of ratio of lymph node metastasis in gastric carcinoma

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Abstract

Background

The purpose of this study was to clarify the outcome of the ratio of the metastatic lymph nodes (RML) in gastric cancer patients.

Methods

The postoperative survival of 650 patients with gastric cancer who underwent D2 curative gastrectomy was analyzed with regard to the RML. The location, number, and RML in the N1 station and in all (N1 and N2) stations were analyzed. These data were compared from the viewpoints of staging accuracy and patient survival.

Results

The RML was classified as follows: RML 0, no involvement; RML 1, 0 to .1; RML 2, .1 to .25; and RML 3, ≥.25. The 5-year survival rates stratified by RML were RML 0, 86%; RML 1, 68%; RML 2, 35%; and RML 3, 16%. Cox model identified all methods of classifying lymph node metastases as independent prognostic indicators in each calculation. However, a second Cox regression revealed that RML was the only independent prognostic factor among the three methods (P<.001). Stage migration was present in 35 cases (15%) when the number was considered. However, only 15 cases (7%) were underdiagnosed when RML was used.

Conclusions

RML is a useful classification of patients with gastric cancer. It may prevent the phenomenon of stage migration.

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Authors and Affiliations

  1. Gastric Surgery Division, Shizuoka Cancer Center, Shizuoka, Japan

    Etsuro Bando MD & Yutaka Yonemura MD

  2. Second Department of Surgery, School of Medicine, Kanazawa University, Kanazawa, Japan

    Etsuro Bando MD, Yutaka Yonemura MD, Keizo Taniguchi MD, Sachio Fushida MD, Takashi Fujimura MD & Koichi Miwa MD

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  1. Etsuro Bando MD
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  2. Yutaka Yonemura MD
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  3. Keizo Taniguchi MD
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  4. Sachio Fushida MD
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  5. Takashi Fujimura MD
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  6. Koichi Miwa MD
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Correspondence to Yutaka Yonemura MD.

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Bando, E., Yonemura, Y., Taniguchi, K. et al. Outcome of ratio of lymph node metastasis in gastric carcinoma. Annals of Surgical Oncology 9, 775–784 (2002). https://doi.org/10.1007/BF02574500

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  • DOI: https://doi.org/10.1007/BF02574500

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