Skip to main content
SpringerLink
Log in

Hepatitis C in haemodialysis and nonuraemic patients: A histopathological study

  • Published:
International Urology and Nephrology Aims and scope Submit manuscript

Abstract

Hepatitis C virus (HCV) is the major cause of posttransfusion non-A, non-B hepatitis. Haemodialysis patients carry the risk of HCV infection. The aim of this study is to compare the morphological changes related to chronic HCV infection found in haemodialysis and nonuraemic patients. Liver biopsies from nine haemodialysis patients and 37 patients with normal renal function were studied. This study shows that haemodialysis patients may have less active and progressive chronic hepatitis C than patients with normal renal function. The number of patients in this study is limited, therefore further studies are needed for definite conclusion.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Genesca, J., Esteban, J. I., Alter, H. J.: Blood-borne non-A, non-B hepatitis: Hepatitis C.Semin. Liver Disease, 11, 147 (1991).

    CAS  Google Scholar 

  2. Sungur, C., Arik, N., Akpolat, T.: Nosocomial transmission of hepatitis C virus to hemodialysis patients: Molecular epidemiology by polymerase chain reaction.Nephron, 71, 363 (1995).

    PubMed  CAS  Google Scholar 

  3. Sampietro, M., Badalamenti, S., Graziani, G.: Nosocomial hepatitis C in dialysis units.Nephron, 74, 251 (1996).

    PubMed  CAS  Google Scholar 

  4. Akpolat, T., Arik, N., Günaydin, M., Utaş, C., Dilek, K., Çaĝlar, Ş., Candan, F., Süleymanlar, G., Paydaş, S., Şen, S., Kürşat, S., Yeksan, M., Akoĝlu, E., Boran, M., Arinsoy, T., Bozfakioĝlu, S., Çamsari, T., Tonbul, Z., Vural, A., Ataman, R.: Prevalence of anti-HCV among haemodialysis patients in Turkey: A multicentre study.Nephrol. Dial. Transplant., 10, 479 (1995).

    PubMed  CAS  Google Scholar 

  5. Davis, C. L., Gretch, D. R., Carithers, R. L.: Hepatitis C virus in renal disease.Current Opinion in Nephrology and Hypertension, 3, 164 (1994).

    Article  PubMed  CAS  Google Scholar 

  6. Akpolat, T., Arik, N., Arinsoy, T., Sungur, C., Bakkaloĝlu, M., Erkan, I., Yasavul, Ü., Turgan, Ç., Çaĝlar, Ş.: High prevalence of antibodies to hepatitis C virus among renal transplant recipients: Correlation with chronic liver dysfunction.Nephron, 64, 163 (1993).

    Article  PubMed  CAS  Google Scholar 

  7. Watanabe, S., Okita, K., Harada, T., Kodama, T., Numa, Y., Takemoto, T., Takahashi, T.: Morphologic studies of the liver cell dysplasia.Cancer, 51, 2197 (1983).

    Article  PubMed  CAS  Google Scholar 

  8. Bach, N., Thung, S. N., Shaffner, F.: The histological features of chronic hepatitis C and autoimmune chronic hepatitis: A comparative analysis.Hepatology, 15, 572 (1992).

    PubMed  CAS  Google Scholar 

  9. International Group: Acute and chronic hepatitis revisited.Lancet, 2, 914 (1977).

    Google Scholar 

  10. Scheuer, P. J.: Classification of chronic viral hepatitis: A need for reassessment.J. Hepatol., 13, 372 (1993).

    Article  Google Scholar 

  11. Knodell, R. G., Ishak, K. G., Black, W. C., Chen, T. S., Craig, R., Kaplowitz, N., Kiernan, T. W., Wollman, J.Hepatology, 1, 431 (1981).

    PubMed  CAS  Google Scholar 

  12. Boletis, J., Delladetsima, J. K., Psimenou, E., Vafiadi, I., Katsoulidou, A., Stathakis, Ch., Kostakis, A., Hatzakis, A., Vosnides, Gr.: Liver biopsy is essential in anti-HCV + haemodialysis patients irrespective of the biochemical and serological findings.Nephrol. Dial. Transplant., 9, 976 (1994).

    Google Scholar 

  13. Wirnsberger, G. H., Juric, Z., Kenner, L., Höfler, G., El-Shabrawi, Y., Winter, E., Horina, J. H., Holzer, H.: Hepatitis C virus (HCV) infection in Styrian haemodialysis units.Nephrol. Dial. Transplant., 9, 1008 (1994).

    Google Scholar 

  14. Barril, G., Traver, J. A.: Risk factors in the transmission of HCV in (HD) patients.Nephrol. Dial. Transplant., 10, 1002 (1995).

    Google Scholar 

  15. Ishitani, S., Nishide, I., Mune, M., Yukawa, S.: Clinico-pathologic studies on type C hepatitis in patients with chronic hemodialysis.Nephrol. Dial. Transplant., 11, A180 (1996).

    Google Scholar 

  16. Nieto, J., Ferreras, I., Mora, F., Caparros, G., Sanchez, A., de la Torre, M., Peces, R.: Liver histological findings in haemodialysis patients with chronic hepatitis C virus infection.Nephrol. Dial. Transplant., 8, 971 (1993).

    Google Scholar 

  17. Alfurayh, O., Sobh, M., Buali, A., Ali, M. A., Barri, Y., Qunibi, W., Taher, S.: Hepatitis C virus infection in chronic haemodialysis patients, a clinicopathologic study.Nephrol. Dial. Transplant., 7, 327 (1992).

    PubMed  CAS  Google Scholar 

  18. Gilli, P., Cavazzini, L., Stabellini, N., Malacarne, F., Soffritti, S., Storari, A.: Histological features of non-A, non-B hepatitis in hemodialysis patients.Nephron, 61, 296 (1992).

    Article  PubMed  CAS  Google Scholar 

  19. Özyilkan, E., Akpolat, T., Arik, N., Köseoĝlu, H. T., Telatar, H.: Characteristics of chronic hepatitis C virus (HCV) infection in patients on maintenance haemodialysis.Nephrol. Dial. Transplant., 9, 1697 (1994).

    PubMed  Google Scholar 

  20. Arista-Nasr, J., Pichardo-Bahena, R., Castaneda, B., Lisker, M., Keirns, C.: Hepatitis C: A disease with a wide morphological spectrum?J. Clin. Gastroenterol., 22, 121 (1996).

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology, Ondokuz Mayis University School of Medicine, Samsun, Turkey

    I. Akpolat, F. Karagöz & B. Kandemir

  2. Department of Gastroenterology, Ondokuz Mayis University School of Medicine, Samsun, Turkey

    E. Özyilkan

  3. Department of Nephrology, Ondokuz Mayis University School of Medicine, Samsun, Turkey

    T. Akpolat

Authors
  1. I. Akpolat
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. Özyilkan
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. F. Karagöz
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. T. Akpolat
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. B. Kandemir
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Akpolat, I., Özyilkan, E., Karagöz, F. et al. Hepatitis C in haemodialysis and nonuraemic patients: A histopathological study. International Urology and Nephrology 30, 349–355 (1998). https://doi.org/10.1007/BF02550322

Download citation

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02550322

Keywords

Search

Navigation