Abstract
Expression of urokinase receptors on peripheral human monocytes from healthy donors and patients with angina pectoris is studied by125I-prourokinase receptor binding assay and flow cytofluorimetry with monoclonal antibodies to the urokinase receptor. Plasma concentration of urokinase is measured by ELISA. It is shown that in patients with angina pectoris plasma content of urokinase is higher by 30%, while the number of free urokinase receptors on monocytes is half lower than that in healthy donors.
Similar content being viewed by others
References
T. L. Krasnikova, V.A. Radvukhin, E. V. Parfenova,et al., Byull. Eksp. Biol. Med.,102, No. 7, 46–48 (1986).
F. Blasi, J. D. Vassali, and K. Dano,J. Cell Biol.,104, No. 4, 801–804 (1987).
M. Conese, A. Nykjer, C. M. Petersen,et al.,,131, No. 6, 1609–1622 (1995).
J. Grondahl-Hansen, N. Agerlin, P. Munkholm-Larsen, et al.,J. Lab. Clin. Med.,111, No. 1, 42–51 (1988).
J. C. Kirchheimer, Y. -H. Nong, and H. G. Remold,J. Immunol.,141, No. 12, 4229–4234 (1988).
J. C. Kirchheimer and H. G. Remold,Blood,74, No. 4, 1396–1402 (1989).
H. Ljunger and D. Bergqvist,Atherosclerosis,50, No. 1, 113–116 (1984).
C. H. Lundgren, H. Sawa, B. E. Sobel, and S. Fujii,Circulation,90 No. 4, 1927–1934 (1994).
A. Mazzone, S. De Servi, G. Ricevuti,et al.,,88, No. 2, 358–363 (1993).
H. Noda-Heiny, A. Daugherty, and B. E. Sobel,Arterioscler. Thromb. Vasc. Biol.,15, No. 1, 37–43 (1995).
A. Nykjer, C. M. Petersen, E. I. Christensen,et al., Biochim. Biophys. Acta,1052, No. 3, 399–407 (1990).
P. N. Raghunath, J. E. Tomaszewski, S. T. Brady,et al., Arterioscler. Thromb. Vasc. Biol.,15, No. 9, 1432–1443 (1995).
E. Ronne, H. Pappot, J. Grondahl-Hansen,et al., Br. J. Haematol.,89, 576–581 (1995).
A. J. Valente, M. M. Rozek, E. A. Sprague, and C. J. Schwartz,Circulation,86, Suppl. 111, 111-20–111-25 (1992).
Author information
Authors and Affiliations
Additional information
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 125, No. 2, pp. 137–139, February, 1998
Rights and permissions
About this article
Cite this article
Krasnikova, T.L., Parfenova, E.V., Aref'eva, T.I. et al. Urokinase receptors on human monocytes in angina pectoris. Bull Exp Biol Med 125, 118–120 (1998). https://doi.org/10.1007/BF02496834
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02496834