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A case of endolymphatic sac tumor with long-term survival

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Abstract

A 72-year-old man developed left facial palsy at age 14 and left-sided hearing loss at age 20. At the age of 59, he presented with gait disturbance, and a large left cerebellopontine angle tumor was detected, which had markedly destroyed the pyramidal bone. The tumor was subtotally resected, but he required two more operations at the ages of 64 and 69 because of tumor regrowth. At the present time, recurrent tumor has destroyed the occipital bone and is invading the scalp. However, eventhough he has several cranial nerve palsies and cerebellar ataxia, he remains in stable condition and demonstrates long-term survival. The patient's surgical specimens revealed a papillary adenoma, which was recently thought to be of endolymphatic sac origin, although the origin of this kind of tumor, whether arising from the middle ear or from the endolymphatic sac, has not been established with certainty so far. In this paper, we provide further evidence that this tumor originates from the endolymphatic sac, based on anatomical, histopathological, and embryological evidence.

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References

  1. Heffner DK (1989) Low grade adenocarcinoma of probable endolymphatic sac origin: a clinicopathologic study of 20 cases. Cancer 64:2292–2302

    Article  PubMed  CAS  Google Scholar 

  2. Li JC, Brackmann DE, Lo WWM, et al (1993) Reclassification of aggressive adenomatous mastoid neoplasms as endolymphatic sac tumors. Laryngoscope 103:1342–1348

    PubMed  CAS  Google Scholar 

  3. Miura K, Tsutsui Y (1996) A case report of low-grade papillary adenocarcinoma of probable endolymphatic sac origin with a review of the literature and differential diagnosis (in Japanese). Byouri to Rinshyou (Pathol Clin Med) 14:251–258

    Google Scholar 

  4. Adam W, Johnson JC, Paul DJ, et al (1982) Primary adenocarinoma of the middle ear. AJNR 3:674–676

    PubMed  CAS  Google Scholar 

  5. Glassock ME, McKennan KX, Levine SC, et al (1987) Primary adenocarcinoma of the middle ear and temporal bone. Arch Otolaryngol Head Neck Surg 113:822–824

    Google Scholar 

  6. Goebel JA, Smith PG, Kemink JL, et al (1987) Primary adenocarinomas of the temporal bone mimicking paragangliomas: radiographic and clinical recognition. Otolaryngol Head Neck Surg 96:231–238

    PubMed  CAS  Google Scholar 

  7. Gulya AJ, Glasscock ME, Pensak ML (1986) Primary adenocarcinoma of the temporal bone with posterior fossa extension: case report. Laryngoscope 96:675–677

    PubMed  CAS  Google Scholar 

  8. Schuller DE, Conley JJ, Goodman JH, et al (1983) Primary adenocarcinoma of the middle ear. Otolaryngol Head Neck Surg 91:280–283

    PubMed  CAS  Google Scholar 

  9. Stone HE, Lipa M, Bell RD (1975) Primary adenocarcinoma of the middle ear. Arch Otolaryngol 101:702–705

    PubMed  CAS  Google Scholar 

  10. Gaffey MJ, Mills SE, Fechner RE, et al (1988) Aggressive papillary middle-ear tumor: a clinicopathologic entity distinct from middle-ear adenoma. Am J Surg Pathol 12:790–797

    PubMed  CAS  Google Scholar 

  11. Benecke JE, Noel FL, Carberry LN, et al (1990) Adenomatous tumors of the middle ear and mastoid. Am J Otol 11:20–26

    PubMed  Google Scholar 

  12. Hassard AD, Boudreau SF, Cron CC (1984) Adenoma of the endolymphatic sac. J Otolaryngol 13:213–216

    PubMed  CAS  Google Scholar 

  13. Amano H, Kinoshita Y, Ito H, et al (1995) Aggressive papillary adenoma of probable endolymphatic sac origin: report of a case (in Japanese) Jibi Inkoka, Tokeibu Geka (Otolaryngol Head Neck Surg) 67:128–132

    Google Scholar 

  14. Folker RJ, Meyerhoff WL, Rushing EJ (1997) Aggressive papillary adenoma of the cerebellopontine angle: case report of an endolymphatic sac tumor. Am J Otolaryngol 18:135–139

    Article  PubMed  CAS  Google Scholar 

  15. Pollak A, Böhmer A, Spycher M, et al (1996) Are papillary adenomas endolymphatic sac tumors? Ann Otol Laryngol 104:613–619

    Google Scholar 

  16. Reijneveld J, Hanlo P, Groenewoud G, et al (1997) Endolymphatic sac tumor: a case report and review of the literature. Surg Neurol 48:368–373

    Article  PubMed  CAS  Google Scholar 

  17. Lo WWM, Applegate LJ, Carberry JN et al (1993) Endolymphatic sac tumors: radiologic appearance. Radiology 189:199–204

    PubMed  CAS  Google Scholar 

  18. Tos M (1984) Anatomy and histology of the middle ear. Clin Rev Allergy 2:267–284

    PubMed  CAS  Google Scholar 

  19. Bloom W, Fawcett DW (1975) A textbook of histology. WB Saunders, Philadelphia, pp 964–992

    Google Scholar 

  20. Arenberg IK, Norback DH, Shambaugh GE (1982) Ultrastructural analysis of endolymphatic sac biopsies: biopsy technique and identification of endolymphatic sac epithelium. Arch Otolaryngol 108:292–298

    PubMed  CAS  Google Scholar 

  21. Bold EL, Wanamaker JR, Hughes GB, et al (1995) Adenomatous lesions of the temporal bone: immunohistochemical analysis and theories of histogenesis. Am J Otol 16:146–152

    PubMed  CAS  Google Scholar 

  22. Zahtz GD, Zielinski B, Abramson AL (1981) Benign adenoma of the middle ear cavity causing facial paralysis. Otolaryngol Head Neck Surg 89:624–628

    PubMed  CAS  Google Scholar 

  23. Batsakis JG (1989) Adenomatous tumors of the middle ear. Ann Otol Rhinol Laryngol 98:749–752

    PubMed  CAS  Google Scholar 

  24. Polinsky MN, Brunberg JA, McKeever PE, et al (1994) Aggressive papillary middle ear tumors: a report of two cases with review of the literature. Neurosurgery 35:493–497

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Neurosurgery, Hirosaki University, School of Medicine, Zaifu-cho 5, 036-8562, Hirosaki, Aomori Prefecture, Japan

    Kenichiroh Asano, Tetsuji Sekiya, Toru Hatayama, Masahiko Tanaka, Atsuhito Takemura & Shigeharu Suzuki

  2. Department of Neurosurgery, Neurological Institute, Tokyo Women's Medical College, Tokyo, Japan

    Osami Kubo

  3. Gerlatric Health Faculties Machida-Sakuranbo, Tokyo, Japan

    Yoshihiro Ishihara

Authors
  1. Kenichiroh Asano
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  2. Tetsuji Sekiya
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  3. Toru Hatayama
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  4. Masahiko Tanaka
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  5. Atsuhito Takemura
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  6. Shigeharu Suzuki
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  7. Osami Kubo
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  8. Yoshihiro Ishihara
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Correspondence to Kenichiroh Asano.

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Asano, K., Sekiya, T., Hatayama, T. et al. A case of endolymphatic sac tumor with long-term survival. Brain Tumor Pathol 16, 69–76 (1999). https://doi.org/10.1007/BF02478905

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  • DOI: https://doi.org/10.1007/BF02478905

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