Skip to main content
SpringerLink
Log in

Antibiotics inhibiting the biosynthesis of cholesterol (a review)

  • Search for New Drugs
  • Published:
Pharmaceutical Chemistry Journal Aims and scope

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. J. Bérdy,Biotekhnologiya, No. 7-8, 13–34 (1995).

    Google Scholar 

  2. J. A. Vida and M. Gordon (eds.),Conformationally Directed Drug Design, New York (1984), pp. 75–103.

  3. G. F. Gauze and Yu. V. Dudnik,Antitumor Antibiotics [in Russian], Meditsina, Moscow (1987).

    Google Scholar 

  4. J. F. Borel,Pharmacol. Rev.,41, 259–371 (1989).

    CAS  Google Scholar 

  5. F. J. Dumont, M. J. Staruch, S. L. Koprak, et al.,J. Immunol.,144, 251–258 (1990).

    PubMed  CAS  Google Scholar 

  6. T. Franclin and G. Snow,Biochemistry of Antimicrobial Action, Chapman and Hall, London (1981).

    Google Scholar 

  7. S. Omura,Proc. of the 7th Int. Symposium on Biology of Actinomycetes, Tokyo (1988), pp. 26–31.

  8. A. S. Trenin,Anibiot. Khimioter.,40(3), 57–62 (1995).

    CAS  Google Scholar 

  9. G. Ya. Shvarts,Khim.-Farm. Zh.,24(8), 13–22 (1990).

    CAS  Google Scholar 

  10. C. R. Sirtori,Pharmacol. Ther.,67(3), 433–447 (1995).

    Article  PubMed  CAS  Google Scholar 

  11. V. H. Hamilton, F.-E. Racocot, H. Zowall, et al.,J. Am. Med. Assoc.,273(13), 1032–1038 (1995).

    Article  CAS  Google Scholar 

  12. The Lovastatin Pravastatin Study Group,Am. J. Cardiol.,71, 810–815 (1993).

    Article  Google Scholar 

  13. B. A. Sidorenko and N. A. Gritsianskii,Kardiologiya,36(6), 97–107 (1996).

    Google Scholar 

  14. N. A. Gratsianskii,Kardiologiya,34(3), 49–62 (1994).

    Google Scholar 

  15. A. N. Klimov and N. G. Nikul'cheva,Lipids, Lipoproteins, and Atherosclerosis [in Russian], Piter, St. Petersburg (1995).

    Google Scholar 

  16. G. R. Thompson,A Handbook of Hyperlipidemia, Current Science, London (1989).

    Google Scholar 

  17. V. S. Repin and V. N. Smirnov,Fundamental Sciences Versus Atherosclerosis [in Russian], Soyuzmedinform, Moscow (1989).

    Google Scholar 

  18. J. Shepherd and C. J. Packard,Trends Pharmacol. Sci.,9(9), 326–329 (1988).

    Article  PubMed  CAS  Google Scholar 

  19. D. J. Betteridge,Diabet. Med.,6(3), 195–218 (1989).

    Article  PubMed  CAS  Google Scholar 

  20. V. S. Repin,Science in USSR, No. 2, 45–50 (1990).

    Google Scholar 

  21. M. S. Brown and J. L. Goldstein,Nature,343, 508–509 (1990).

    Article  PubMed  CAS  Google Scholar 

  22. V. S. Repin,Usp. Sovr. Biol.,109(1), 120–129 (1990).

    CAS  Google Scholar 

  23. V. A. Kosykh, D. K. Novikov, I. N. Trakht, et al.,Lipids,26(10), 799–805 (1991).

    PubMed  CAS  Google Scholar 

  24. C. A. Dujovne and W. S. Harris,Palo Alto (Calif.),29, 265–288, (1989).

    CAS  Google Scholar 

  25. N. A. Gratsianskii,Kardiologiya,34(3), 63–69 (1994).

    Google Scholar 

  26. L. A. Carlson,Pharmacol. Toxicol.,65, Suppl. 1, 58 (1989).

    Google Scholar 

  27. A. S. Kesaniemi and S. M. Grundy,Arteriosclerosis,4, 41–48 (1984).

    PubMed  CAS  Google Scholar 

  28. F. Lepre and S. Crane,Austral. N. Z. J. Med.,20(3), Suppl. 1, 542 (1990).

    Google Scholar 

  29. R. G. Bakker-Arkema, M. H. Davidson, R. J. Goldstein, et al.,J. Am. Med. Assoc.,275(2), 128–133 (1996).

    Article  CAS  Google Scholar 

  30. P. J. Lansberg, Y. B. Mitchel, D. Shapiro, et al.,Atherosclerosis,116(2), 153–162 (1995).

    Article  PubMed  CAS  Google Scholar 

  31. A. Endo, M. Kuroda, and Y. Tsujita,J. Antibiot. (Tokyo),29(12), 1346–1348 (1976).

    CAS  Google Scholar 

  32. A. Endo,J. Antibiot. (Tokyo),33(3), 334–336 (1980).

    CAS  Google Scholar 

  33. A. W. Alberts, J. Chen, G. Kuron, et al.,Proc. Natl. Acad. Sci. USA,77(7), 3957–3961 (1980).

    Article  PubMed  CAS  Google Scholar 

  34. A. Endo and K. Hasumi,J. Antibiot. (Tokyo),38 (3), 321–327 (1985).

    CAS  Google Scholar 

  35. A. Endo, K. Hasumi, and S. Negishi,J. Antibiot. (Tokyo),38(3), 420–422 (1985).

    CAS  Google Scholar 

  36. A. Endo, K. Hasumi, A. Yamada A., et al.,J. Antibiot. (Tokyo),39(11), 1609–1610 (1986).

    CAS  Google Scholar 

  37. S. Murakawa, K. Sakai, and A. Endo,J. Antibiot. (Tokyo),47(1), 108–109 (1994).

    CAS  Google Scholar 

  38. A. Endo, H. Yamashita, H. Naoki, et al.,J. Antibiot. (Tokyo),38(3), 328–332 (1985).

    CAS  Google Scholar 

  39. M. Arai, N. Serizawa, A. Terahara, et al.,Sankyo Kenkyusho Nempo,40, 1–38 (1988).

    CAS  Google Scholar 

  40. R. H. Abeles and C. E. Nakamura,Biochemistry,24, 1364–1376 (1985).

    Article  PubMed  Google Scholar 

  41. A. Endo,J. Med. Chem.,28, 401–405 (1985).

    Article  PubMed  CAS  Google Scholar 

  42. W. F. Hofman, A. W. Alberts, P. S. Anderson, et al.,J. Med. Chem.,29, 849–852 (1986).

    Article  Google Scholar 

  43. Y. Tsujita, M. Kuroda, Y. Shimada, et al.,Biochim. Biophys. Acta,877, 50–60 (1986).

    PubMed  CAS  Google Scholar 

  44. N. Serisawa, K. Nakagawa, K. Hamano, et al.,J. Antibiot. (Tokyo),36, 604–607 (1983).

    Google Scholar 

  45. H. Joshua, M. S. Schwartz, K. E. Wilson,J. Antibiot. (Tokyo),44(3), 366–370 (1991).

    CAS  Google Scholar 

  46. H. Yamashita, S. Tsubokawa, and A. Endo,J. Antibiot. (Tokyo),48(5), 605–609 (1995).

    Google Scholar 

  47. G. AIbert-Schonberg, H. Joshna M. B. Lopez, et al.,J. Antibiot. (Tokyo),34(5), 507–512 (1981).

    Google Scholar 

  48. Y. K. Lam, V. P. Gullo, R. T. Goegelman, et al.,J. Antibiot. (Tokyo),34(5), 614–616 (1981).

    CAS  Google Scholar 

  49. C. H. Heathcock and T. Rosen,Tetrahedron,42(18), 4908–4951 (1986).

    Google Scholar 

  50. P. J. Connolly, C. D. Westtin, D. A. Loughney, et al.,J. Med. Chem.,36, 3674–3685 (1993).

    Article  PubMed  CAS  Google Scholar 

  51. B. D. Roth, D. R. Sliskovic, and B. K. Trivedi,Ann. Rep. Med. Chem.,24, 147–156 (1989).

    Article  CAS  Google Scholar 

  52. S. Y. Sit, R. A. Parker, I. Motok, et al.,J. Med. Chem.,33, 2989–2999 (1990).

    Article  Google Scholar 

  53. G. Beck, K. Kesseler, E. Baader, et al.,J. Med. Chem.,33, 52–60 (1990).

    Article  PubMed  CAS  Google Scholar 

  54. B. D. Roth, C. J. Biankley, A. W. Chucholowski, et al.,J. Med. Chem.,34, 357–366 (1991).

    Article  PubMed  CAS  Google Scholar 

  55. M. Ogasawara, N. Naruse, A. Yoshimura, et al.,J. Antibiot. (Tokyo),46(5), 866–868 (1993).

    CAS  Google Scholar 

  56. A. K. Gayen and D. M. Peffley,Arch. Biochem. Biophys.,322(2), 475–485 (1995).

    Article  PubMed  CAS  Google Scholar 

  57. B. R. Krause and R. S. Newton,Atherosclerosis,117(2), 237–244 (1995).

    Article  PubMed  CAS  Google Scholar 

  58. G. A. Cook, B. Khan, and M. Heimberg,Biochem. Biophys. Res. Commun.,150(3), 1077–1082 (1988).

    Article  PubMed  CAS  Google Scholar 

  59. P. H. Berry, J. S. Macdonald, A. W. Alberts, et al.,Am. J. Pathol.,132(3), 427–443 (1988).

    PubMed  CAS  Google Scholar 

  60. W. R. Garnett,Am. J. Health Syst. Pharm.,52(15), 1639–1645 (1995).

    PubMed  CAS  Google Scholar 

  61. P. E. Smith, R. S. Eydelloth, S. J. Grossman, et al.,J. Pharmacol. Exp. Ther.,257(3), 1225–1235 (1991).

    PubMed  CAS  Google Scholar 

  62. K. Hasumi, M. Arahira K. Sakai, and A. Endo,J. Antibiot. (Tokyo),40(2), 224–226 (1987).

    CAS  Google Scholar 

  63. H. Ogawa, K. Hasumi, K. Sakai, et al.,J. Antibiot. (Tokyo),44(7), 762–767 (1991).

    CAS  Google Scholar 

  64. J. K. Park, K. Sakai, H. Ogawa, et al.,J. Antibiot. (Tokyo),46(7), 1170–1172 (1993).

    CAS  Google Scholar 

  65. D. Kunt, T. Arke, H. Besl, et al.,J. Antibiot. (Tokyo),43(11), 1413–1419 (1990).

    Google Scholar 

  66. K. D. Clinkenbeard, W. D. Reed, R. A. Mooney, and M. D. Lane,J. Biol. Chem. 250(8), 3108–3116 (1975).

    PubMed  CAS  Google Scholar 

  67. K. D. Clinkenbeard, T. Sugiyama, J. Moss, et al.,J. Biol. Chem.,248(7), 2275–2284 (1973).

    PubMed  CAS  Google Scholar 

  68. K. D. Clinkenbeard, T. Sugiyama, W. D. Reed, et al.,J. Biol. Chem.,250(8), 3124–3135 (1975).

    CAS  Google Scholar 

  69. H. Tomoda, H. Kumagai, H. Tanaka, et al.,Biochem. Biophys. Acta,922, 351–356 (1987).

    PubMed  CAS  Google Scholar 

  70. H. Tomoda, H. Kumagai, Y. Takahaschi, et al.,J. Antibiot. (Tokyo),41(3), 247–249 (1988).

    CAS  Google Scholar 

  71. H. Kumagai, H. Tomoda, and S. Omura,J. Antibiot. (Tokyo),43(4), 397–402 (1990).

    CAS  Google Scholar 

  72. S. Omura, H. Tomoda, and H. Kumagai,J. Antibiot. (Tokyo),40(9), 1356–1357 (1987).

    CAS  Google Scholar 

  73. H. Tomoda, H. Kumagai, H. Tanaka, and S. Omura,J. Antibiot. (Tokyo),46(5), 872–873 (1993).

    CAS  Google Scholar 

  74. T. Sunazuka, K. Tsuzuki, H. Kumagai, et al.,J. Antibiot. (Tokyo),45(7), 1139–1147 (1992).

    CAS  Google Scholar 

  75. C. Kotake, T. Yamasaki, T. Moriyama, et al.,J. Antibiot. (Tokyo),45(9), 1442–1450 (1992).

    CAS  Google Scholar 

  76. C. Dufrense, K. E. Wilson, D. Zink, et al.,Tetrahedron,48, 10221–10226 (1992).

    Article  Google Scholar 

  77. M. W. Dawson, J. E. Farting, P. S. Marshal, et al.,J. Antibiot. (Tokyo),45(5), 639–647 (1992).

    CAS  Google Scholar 

  78. P. J. Sidebottom, R. M. Highcocr, S. J. Lane, et al.,J. Antibiot. (Tokyo),45, 648–658 (1992).

    CAS  Google Scholar 

  79. A. Baxter, B. J. Fitzgerald, J. L. Hutson, et al.,J. Biol. Chem.,267, 11705–11708 (1992).

    PubMed  CAS  Google Scholar 

  80. J. D. Bergstrom, M. M. Kurtz, D. J. Rew, et al.,Proc. Nat. Acad. Sci. USA,90, 80–84 (1993).

    Article  PubMed  CAS  Google Scholar 

  81. S. Lindsey and H. J. Harwood, Jr.,J. Biol. Chem.,270, 9083–9096 (1995).

    Article  PubMed  CAS  Google Scholar 

  82. E. M. Carreira and J. Du Bois,J. Am. Chem. Soc.,117, 8106–8125 (1995).

    Article  CAS  Google Scholar 

  83. W. M. Blows, G. Foster, S. J. Lane, et al.,J. Antibiot. (Tokyo),47(7), 740–754 (1994).

    CAS  Google Scholar 

  84. O. D. Hensens, C. Dufresne, J. M. Liesch, et al.,Tetrahedron Lett.,34, 399–405 (1993).

    Article  CAS  Google Scholar 

  85. M. N. Pompipom, N. N. Girotra, R. L. Bugianesi, et al.,J. Med. Chem.,37, 4031–4051 (1994).

    Article  Google Scholar 

  86. C. A. Jones, P. J. Sidebottom, and R. J. P. Cannell,J. Antibiot. (Tokyo),45(9), 1492–1498 (1992).

    CAS  Google Scholar 

  87. R. J. P. Cannell, M. J. Dawson, R. S. Hale, et al.,J. Antibiot. (Tokyo),46(9), 1381–1389 (1993).

    CAS  Google Scholar 

  88. R. F. Middleton, G. Foster, R. J. P. Cannell, et al.,J. Antibiot. (Tokyo),48(4), 311–316 (1995).

    CAS  Google Scholar 

  89. H. Sasaki, T. Hosokawa, M. Sawada, and K. Ando,J. Antibiot. (Tokyo),26, 676–680 (1973).

    CAS  Google Scholar 

  90. J. Magae, K. Nagai, K. Ando K, et al.,J. Antibiot. (Tokyo),36(7), 892–899 (1983).

    CAS  Google Scholar 

  91. A. S. Trenin, L. P. Terekhova, I. V. Tolstykh, et al.,Abstr. of Papers Symp. “Lioproteins and Atherosclerosis”, [in Russian], St. Petersburg (1995), p. 110.

  92. M. Sawada, T. Hasokawa, T. Okutomi, et al.,J. Antibiot. (Tokyo),26, 681–686 (1973).

    CAS  Google Scholar 

  93. I. Yamamoto, M. Nakagawa, Y. Hayakawa, et al.,J. Antibiot. (Tokyo),40(10), 1452–1454 (1987).

    CAS  Google Scholar 

  94. A. Kawashima, Y. Nakamura, Y. Ohta, et al.,J. Antibiot. (Tokyo),45(2), 207–212 (1992).

    CAS  Google Scholar 

  95. S. Grabley, P. Hammann, K. Hutter, et al.,J. Antibiot. (Tokyo),45(7), 1176–1181 (1992).

    CAS  Google Scholar 

  96. S. Grabley, E. Granzer, K. Hutter, et al.,J. Antibiot. (Tokyo),45(1), 56–65 (1992).

    CAS  Google Scholar 

  97. D. Lewis, H. Galczenski, S. Needle, et al.,Steroids,60(7), 475–483 (1995).

    Article  PubMed  CAS  Google Scholar 

  98. M. Kuroda and A. Endo,Biochem. Biophys., Acta,486, 70–81 (1977).

    CAS  Google Scholar 

  99. N. H. Georgopapadakou and A. Bertasso,Antimicrob. Agents Chemother,36(8), 1779–1781 (1992).

    PubMed  CAS  Google Scholar 

  100. V. Joly, J. Bolard, and P. Yeni,Antimicrob. Agents Chemother.,36(9), 1799–1804 (1992).

    PubMed  CAS  Google Scholar 

  101. T. Kuchta, S. Leka, P. Farkaš, et al.,Antimicrob. Agents Chemother.,39(7), 1538–1541 (1995).

    PubMed  CAS  Google Scholar 

  102. O. Shimokawa and H. Nakayama,Antimicrob. Agents Chemother.,36(8), 1626–1629 (1992).

    PubMed  CAS  Google Scholar 

  103. H. Vanden Bossche, P. Marichal, L. Le Jeune, et al.,Antimicrob. Agents Chemother.,37(10), 2101–2105 (1993).

    Google Scholar 

  104. J. A. Urbina, K. Lazardi, E. Marchan, et al.,Antimicrob. Agents Chemother.,37(3), 580–591 (1993).

    PubMed  CAS  Google Scholar 

  105. P. Glellier, A. Valentin, V. Millerioux, et al.,Antimicrob. Agents Chemother.,38(5), 1144–1148 (1994).

    Google Scholar 

  106. R. Ikeura, S. Murakawa, and A. Endo,J. Antibiot. (Tokyo),41(8), 1148–1150 (1988).

    CAS  Google Scholar 

  107. N. S. Landau, N. A. Baranova, V. G. Kreier, et al.,Microbiologiya,60(3), 479–484 (1991).

    CAS  Google Scholar 

  108. V. G. Kreier, S. N. Vybornykh, N. A. Baranova, and N. S. Egorov,Anibiot. Khimioter.,38(10–11), 16–19 (1993).

    Google Scholar 

  109. J. O'Sullivan, D. W. Phillipson, D. R. Kirsch, et al.,J. Antibiot. (Tokyo),45 (3), 306–312 (1992).

    Google Scholar 

  110. S. Matsukuma, T. Ohtsuka, H. Kotaki, et al.,J. Antibiot. (Tokyo),45(2), 151–159 (1992).

    CAS  Google Scholar 

  111. R. E. Schwartz, C. Dufresne, and J. E. Flor,J. Antibiot. (Tokyo),44(5), 463–471 (1991).

    CAS  Google Scholar 

  112. Y. Aoki, T. Yamazaki, M. Kondoh, et al.,J. Antibiot. (Tokyo),45(2), 160–170, (1992).

    CAS  Google Scholar 

  113. Y. Aoki, F. Yoshihara, M. Kondoh, et al.,Antimicrob. Agents Chemother.,37(12), 2662–2667 (1993).

    PubMed  CAS  Google Scholar 

  114. A. Endo and M. Kuroda,J. Antibiot. (Tokyo),29(8), 841–843 (1976).

    CAS  Google Scholar 

  115. S. Kudam, J. Poddig, P. Humphrey, et al.,J. Antibiot. (Tokyo),47(7), 836–839 (1994).

    Google Scholar 

  116. S. M. Mikulski, A. Viera, Z. Darzynkiewicz, and K. Shogen,Br. J. Cancer,66, 304–310 (1992).

    PubMed  CAS  Google Scholar 

  117. D. Samid, W. R. Hudgins, S. Shack, et al.,Abstr. of the 8th Natl. Cancer Institute EORTC Symp. on New Drugs, Amsterdam (1994), p. 139.

  118. A. Thibault, D. Samid, W. D. Figg, et al.,Abstr. of the 8th Natl. Cancer Institute EORTC Symp. on New Drugs, Amsterdam (1994), p. 139.

  119. J. Magae, T. Hosokawa, K. Ando, et al.,J. Antibiot. (Tokyo),35, 1547–1552 (1982).

    CAS  Google Scholar 

  120. J. Magae, S. Suzuki, K. Nagai, et al.,Cancer Res.,46, 1073–1078 (1986).

    PubMed  CAS  Google Scholar 

  121. E. M. Repko and W. A. MalteseJ. Biol. Chem.,264, 9945–9952, (1989).

    PubMed  CAS  Google Scholar 

  122. L. J. Vatten and O. P. Foss,Cancer Res.,50, 2341–2346 (1990).

    PubMed  CAS  Google Scholar 

  123. J. D. Bergstrom, C. Dufresne, G. F. Bills, et al.,Ann. Rev. Microbiol.,49, 607–639 (1995).

    Article  CAS  Google Scholar 

  124. N. A. Gratsianskii,Kardiologiya,35(5), 76–79 (1995).

    Google Scholar 

  125. S. M. Wrenn, Jr., J. S. Parks, F. W. Immermann, et al.,J. Lipid Res.,36(6), 1199–1210 (1995).

    PubMed  CAS  Google Scholar 

  126. T.-S. Jeong, S.-U. Kim, K.-H. Son, et al.,J. Antibiot. (Tokyo),48(8), 751–756 (1995).

    CAS  Google Scholar 

  127. S. Omura, H. Tomoda, Y. K. Kim, et al.,J. Antibiot. (Tokyo),46(7), 1168–1169 (1993).

    CAS  Google Scholar 

  128. R. Obata, T. Sunazuka, L. Zhvorong, et al.,J. Antibiot. (Tokyo),48(7), 749–750 (1995).

    CAS  Google Scholar 

  129. K. Sakai, K. Watanabe, K. Mazuda, et al.,J. Antibiot. (Tokyo),48(6), 447–456 (1995).

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Research Institute of New Antibiotics, Russian Academy of Medical Sciences, Moscow, Russia

    A. S. Trenin & G. S. Katrukha

Authors
  1. A. S. Trenin
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. S. Katrukha
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 31, No. 9, pp. 5–16, September, 1997.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Trenin, A.S., Katrukha, G.S. Antibiotics inhibiting the biosynthesis of cholesterol (a review). Pharm Chem J 31, 452–463 (1997). https://doi.org/10.1007/BF02464303

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02464303

Keywords

Search

Navigation