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Immunohistochemical studies of the structural bases of inhibition in the central cerebellar nuclei in mice

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Abstract

The distribution of glutamate decarboxylase-immunoreactive structures in the central nuclei of the cerebellum, its first afferent component, was studied at the light and electron microscope levels. Axosomatic, axodendritic, and axospinous synapses were detected, in which the presynaptic parts contained glutamate decarboxylase (GDC); this enzyme is involved in GABA synthesis. Additionally, these investigations revealed axoaxonal synapses in which both poles were GDC-reactive. The central nuclei of the cerebellum were found to have an intrinsic GABAergic system.

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Authors and Affiliations

  1. Department of Morphology, Scieence Research Institute of Experimental Medicine, Russian Academy of Medical Sciences, 12 Academician Pavlov Street, 197376, St. Petersburg, Russia

    E. G. Gilerovich

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Translated from Rossiiskii Fiziologicheskii Zhurnal imeni I. M. Sechenova, Vol. 84, No. 12, pp. 1325–1332, December, 1998.

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Gilerovich, E.G. Immunohistochemical studies of the structural bases of inhibition in the central cerebellar nuclei in mice. Neurosci Behav Physiol 30, 201–206 (2000). https://doi.org/10.1007/BF02463159

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  • DOI: https://doi.org/10.1007/BF02463159

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