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Donor-specific transfusion via the portal venous route induces prolongation of H-2-compatible but not H-2-incompatible cardiac graft survival

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Transplant International

Abstract

In the H-2-compatible donor-recipient combination (BALB/c→DBA/2), pretransplant donor-specific blood transfusion (DST) via the portal venous (PV) route significantly prolonged cardiac graft survival. DST via the intravenous (IV) route (systemic circulation) also showed a marked prolongation of heart tissue transplant survival in this model. In the H-2-incompatible combination (BALB/c→CBA/H), DST via the IV — but not via the PV — route resulted in accelerated graft rejection.

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Authors and Affiliations

  1. Department of Histology and Embryology, Institute of Biostructure, Medical School, Chałubińskiego 5, PL-02-004, Warsaw, Poland

    D. Górecki, M. Łupińska, A. Kruszewski & J. Czyźyk

  2. Department of Transplantology, Institute of Biostructure, Medical School, Chałubińskiego 5, PL-02-004, Warsaw, Poland

    M. Jakóbisiak

Authors
  1. D. Górecki
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  2. M. Jakóbisiak
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  3. M. Łupińska
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  4. A. Kruszewski
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  5. J. Czyźyk
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Górecki, D., Jakóbisiak, M., Łupińska, M. et al. Donor-specific transfusion via the portal venous route induces prolongation of H-2-compatible but not H-2-incompatible cardiac graft survival. Transplant Int 2, 199–202 (1989). https://doi.org/10.1007/BF02414534

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