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Cerebrospinal fluid IgG changes in subacute sclerosing panencephalitis in the various stages of the disease and during isoprinosine therapy

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Abstract

The cerebrospinal fluid (CSF) levels of IgG and the separation of the CSF and serum proteins by isoelectric focusing (IEF) were studied in 5 patients with subacute sclerosing panencephalitis (SSPE). Oligoclonal IgG fractions were found in the CSF of all the patients. The CSF IgG, IgG-Index and IgG SYN values were higher in the patients observed in the earlier than in those seen in the later stages of the disease. 1 of the 3 patients treated with isoprinosine presented a partial clinical remission accompanied by an increase in the parameters of intrathecal IgG synthesis.

Sommario

In 5 pazienti affetti da panencefalite sclerosante subacute (PESS) sono stati studiati i livelli liquorali di IgG ed il frazionamento delle proteine liquorali e sieriche mediante isoelettrofocalizzazione (IEF). In tutti i pazienti sono state riscontrate frazioni di IgG oligoclonali nel liquido cerebrospinale (LCS). Nei soggetti giunti alla osservazione in fasi della malattia più precoci si sono osservati valori di IgG liquorali, di IgG-Index e di IgG SYN più elevati rispetto agli altri in stadio più avanzato. Uno dei tre pazienti trattati con Isoprinosina ha presentato una parziale remissione clinica, accompagnata da incremento dei parametri di sintesi intratecale di IgG.

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Authors and Affiliations

  1. Istituto di Clinica Neurologica, Università di Pavia, Via Palestro 3, 27100, Pavia, (Italia)

    Poloni M., Rocchelli B. & Besana D.

  2. Cattedra di Neuropsichiatria Infantile, Università di Pavia, Via Palestro 3, 27100, Pavia, (Italia)

    Lanzi G. & Rosano Burgio F.

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  1. Poloni M.
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  2. Rocchelli B.
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  3. Lanzi G.
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  4. Rosano Burgio F.
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  5. Besana D.
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Poloni, M., Rocchelli, B., Lanzi, G. et al. Cerebrospinal fluid IgG changes in subacute sclerosing panencephalitis in the various stages of the disease and during isoprinosine therapy. Ital J Neuro Sci 2, 177–184 (1981). https://doi.org/10.1007/BF02335441

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