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Monocrotaline-induced Budd-Chiari syndrome in monkeys

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Abstract

Budd-Chiari syndrome was produced in adultMacaca speciosa monkeys within 3 months by the parenteral administration of the pyrrolizidine alkaloid monocrotaline. These animals developed ascites, distended abdominal veins, hypoproteinemia, and an increase in portal venous pressure. The vascular lesions included partial to complete occlusion of hepatic veins throughout the liver. These venous alterations were initiated by endothelial lysis. As a result of the altered permeability, blood components collected throughout the vessel wall, producing marked disruption. Occlusion of the affected vessels followed the encroachment of the thickened edematous wall on the lumen. Eventually these hepatic veins underwent fibrous connective tissue repair, giving rise to widespread focal fibrosis throughout the livers.

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Authors and Affiliations

  1. From the Department of Pathology, University of Wisconsin Medical School and the Regional Primate Research Center, Madison, Wis.

    J. R. Allen PhD & L. A. Carstens BS

Authors
  1. J. R. Allen PhD
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  2. L. A. Carstens BS
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Additional information

Supported by USPHS FR-0167 and HE-10941.

Presented in part at the Sixty-Seventh Annual Meeting of the American Association of Pathologists and Bacteriologists, St. Louis, March 8, 1970.

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Allen, J.R., Carstens, L.A. Monocrotaline-induced Budd-Chiari syndrome in monkeys. Digest Dis Sci 16, 111–121 (1971). https://doi.org/10.1007/BF02284445

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  • DOI: https://doi.org/10.1007/BF02284445

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