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Stability of corticosteroids under anaerobic conditions

VI. Kinetics of the decomposition of prednisolone and the appearance of some decomposition products in aqueous solution under anaerobic conditions

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Abstract

The kinetics of decomposition of prednisolone in aqueous solution were studied under anaerobic conditions at 100°C within the pH range 1.8–8.3. At pH=2.5 prednisolone is most stable. Between pH=5.0 and pH=6.0 the decomposition rate is nearly independent of the pH value. The decomposition products, 17-deoxy-21-dehydroprednisolone, 17-deoxyprednisolone, the 17-ketosteroid and the D-homosteroid were analysed quantitatively. The total amount of acidic decomposition products was approximated. Below pH=5.5 prednisolone decomposes to 17-deoxy-21-dehydroprednisolone. However, at higher pH values a mixture of decomposition products appears. All analyses were performed by a stability indicating high performance liquid Chromatographic method using uv detection.

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Authors and Affiliations

  1. Department of Analytical Pharmacy, Faculty of Pharmacy, State University of Utrecht, Catharijnesingel 60, 3511, GH Utrecht, The Netherlands

    D. Dekker & J. H. Beijnen

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  1. D. Dekker
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  2. J. H. Beijnen
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Part v, seeDekker, D. (1980)Pharm. Weekblad Sci. Ed. 2, 87.

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Dekker, D., Beijnen, J.H. Stability of corticosteroids under anaerobic conditions. Pharmaceutisch Weekblad Scientific Edition 2, 1116–1120 (1980). https://doi.org/10.1007/BF02273268

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  • DOI: https://doi.org/10.1007/BF02273268

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