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Effects of ethanol on the gastric mucosa of the Heidenhain pouch of dogs

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Abstract

The effect of ethanol on the mucosa of the Heidenhain pouch in dogs was studied by instilling ethanol in concentrations of 10, 20 and 40% using changes in ionic fluxes of an acid solution and mucosal alterations to measure the effects of ethanol. The instillation of 20 or 40% ethanol resulted in increased insorption of H+ and increased exorption of Na+ into the pouch lumen. Following the administration of 20 and 40% ethanol, the mucous layer and mucin content of the lining epithelial cells decreased markedly. Hourly bathing with the acid test solution aggravated the injury and induced bleeding, but hourly instillation of a buffer solution minimized the damage. Ionic fluxes returned to pre-ethanol levels 2 hr after 20% ethanol and 3–4 hr after 40% ethanol. Partial restoration of mucosal damage occurred in 4–6 hr and was complete in 24 hr.

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Authors and Affiliations

  1. Temple University Health Sciences Center, 3401 North Broad Street, 19140, Philadelphia, Pa

    Vicente P. Dinoso MD, William Y. Chey MD, Herman Siplet BS & Stanley H. Lorber MD

Authors
  1. Vicente P. Dinoso MD
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  2. William Y. Chey MD
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  3. Herman Siplet BS
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  4. Stanley H. Lorber MD
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Additional information

Supported by NIMH Grant No. 15614-01 and the Licensed Beverage Industry, Inc, New York, NY.

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Dinoso, V.P., Chey, W.Y., Siplet, H. et al. Effects of ethanol on the gastric mucosa of the Heidenhain pouch of dogs. Digest Dis Sci 15, 809–817 (1970). https://doi.org/10.1007/BF02236042

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  • DOI: https://doi.org/10.1007/BF02236042

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