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Caprine arthritis-encephalitis syndrome (CAE): A review

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Abstract

Caprine arthritis-encephalitis syndrome (CAE) is a viral disease of domestic goats characterized by chronic proliferative synovitis and periarthritis of adult goats while acute afebrile leukoencephalomyelitis is characteristic in goat kids. The causative agent, a Lentivirus, is transmitted from adult goats to kids via the colostrum or lateral transmission also occurs.

The CAE virus is worldwide in distribution. All breeds and ages of goats. are susceptible to infection, and once established it persists throughout the animal's life. A diagnosis can be based on the clinical signs, pathological changes, and demonstration of serum antibody levels.

A vaccine is not available. Control or eradication of the disease is based on periodic serological testing, culling of all CAE antibody-positive animals, and separation of kids from adults following birth.

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References

  • Adams, D. S., 1979. Pathogenetic studies on the arthritis of viral caprine arthritis-encephalitis. Dis. Abstracts International, 40B: 1638.

    Google Scholar 

  • Adams, D. S., 1982. The meaning of the agar gel immunodiffusion test (AGID) for antibody against caprine arthritis encephalitis virus (CAEV). Dairy Goat J., 60: 633–635.

    Google Scholar 

  • Adams, D. S. and Crawford, T. B., 1980. CAE: a viral arthritis-encephalitis syndrome in goats. Int. Goat and Sheep Res., 1: 168–172.

    Google Scholar 

  • Adams, D. S., Crawford, T. B. and Klevjer-Anderson, P., 1980a. A pathogenetic study of the early connective tissue lesions of viral caprine arthritisencephalitis. Am. J. Path., 99: 257–278.

    Google Scholar 

  • Adams, D. S., Crawford, T. B., Banks, K. L., McGuire, T. C. and Perryman, L. E., 1980b. Immune responses of goats persistently infected with caprine arthritis-encephalitis virus. Inf. Immunity., 28: 421–427.

    Google Scholar 

  • Adams, D. S., Mugeny, B. M., Allonby, E. W., Bell, J. P., Waghela, S. and Helnonen, R., 1983a. Observations on caprine arthritis-encephalitis in Kenya. Vet. Rec., 112: 227–228.

    Google Scholar 

  • Adams, D. S., Klevjer-Anderson, P., Carlson, J. L., McGuire, T. C. and Gorham, J. R., 1983b. Transmission and control of caprine arthritis-encephalitis virus. Am. J. Vet. Res., 44: 1670–1675.

    Google Scholar 

  • Banks, K. L., Adams, D. S., McGuire, T. C. and Carlson, J., 1983. Experimental infection of sheep by caprine arthritis-encephalitis virus and goats by progressive pneumonia virus. Am. J. Vet. Res., 44: 2307–2311.

    Google Scholar 

  • Barlow, R. M., Robertson, J. M., Owen, E. C. and Proudfoot, R., 1962. A condition in the goat resembling swayback in lambs. Vet. Rec., 74: 737–739.

    Google Scholar 

  • Baxendell, S. A., 1980. Caprine nervous diseases-caprine limb and joint conditions. Proc. #52 (Goats), the post-graduate committee in Vet. Sci. The University of Sydney, 52: 333–341, 369–372.

    Google Scholar 

  • Blood, D. C., Henderson, J. A., and Radostits, O. M. (eds.), 1979. Veterinary Medicine, Lea and Febiger, Philadelphia, pp. 695.

    Google Scholar 

  • Cheevers, W. P., Roberson, S., Klevjer-Anderson, P. and Crawford, T. B., 1981: Characterization of caprine arthritis-encephalitis virus: a retrovirus of goats. Archives of Virology, 67: 111–117.

    Google Scholar 

  • Chung, Y. S. and O'Sullivan, B. M., 1982. Isolation of caprine-arthritis virus and detection of agar-gel immunodiffusion antibodies in goats. Aust. Vet. J., 58: 37–38.

    Google Scholar 

  • Clements, J. E., Narayan, O. and Cork, L. C., 1980. Biochemical characterization of the virus causing leukoencephalitis and arthritis in goats. J. General Virol., 50: 423–427.

    Google Scholar 

  • Coackley, W., Smith, V. W., Marker, D. and Dickson, J., 1981. Isolation of caprine syncytial retroviruses. Aust. Vet. J., 57: 480–481.

    Google Scholar 

  • Cordy, D. R. and Knight, H. D., 1978. California goats with a disease resembling enzootic ataxia or swayback. Vet. Path., 15: 179–185.

    Google Scholar 

  • Cork, L. C., 1976. Differential diagnosis of viral leukoencephalomyelitis of goats. J. Am. Vet. Med. Assoc., 169: 1303–1306.

    Google Scholar 

  • Cork, L. C. and Davis, W. C., 1975. Ultrastructural features of viral leukoencephalomyelitis of goats. Lab. Invest., 32: 359–365.

    Google Scholar 

  • Cork, L. C. and Narayan, O., 1980. The pathogenesis of viral leukoencephalomyelitis-arthritis of goats. 1. Persistent viral infection with progressive pathologic changes. Lab. Invest., 42: 596–602.

    Google Scholar 

  • Cork, L. C., Gorham, J. R., Crawford, T. B., Piper, R. C. and Hadlow, W. J., 1973. Infectious leukoencephalitis of goats. Federation Proc., 32: 849.

    Google Scholar 

  • Cork, L. C., Hadlow, W. J., Crawford, T. B., Gorham, J. R. and Piper, R. C., 1974a. Infectious leukoencephalomyelitis of young goats. J. Inf. Dis., 129: 134–141.

    Google Scholar 

  • Cork, L. C., Hadlow, W. J., Gorham, J. R., Piper, R. C. and Crawford, T. B., 1974b. Pathology of viral leukoencephalomyelitis of goats. Acta. Neuropath., 29: 281–292.

    Google Scholar 

  • Cork, L., Narayan, O., Clements, J., Griffin, D., Bukowski, J. and Strandberg, J., 1978. Viral leukoencephalomyelitis of goats: isolation and preliminary characterizations of the agent. Proc. Amer. Coll. Vet. Pathologists, pp. 293.

  • Cork, L. C., Narayan, O., Strandberg, J. D., Clements, J. and Griffin, D., 1980. Viral leukoencephalomyelitis-arthritis of goats: pathogenesis of the persistent viral infection. J. Neuropath. Exper. Neurol. 39: 346.

    Google Scholar 

  • Crawford, T. B. and Adams, D. S., 1981. Caprine arthritis-encephalitis: clinical features and presence of antibody in selected goat populations. J. Am. Vet. Med. Assoc., 178: 713–719.

    Google Scholar 

  • Crawford, T. B., Adams, D. S., Cheevers, W. P. and Cork, L. C., 1980a. Chronic arthritis in goats caused by a retrovirus. Science, 207: 997–999.

    Google Scholar 

  • Crawford, T. B., Adams, D. S., Sande, R. D., Gorham, J. R. and Henson, J. B., 1980b. The connective tissue component of the caprine arthritis-encephalitis syndrome. Am. J. Path. 100: 443–454.

    Google Scholar 

  • Dahlberg, J. E., Gaskin, J. M. and Perk, K., 1981. Morphological and immunological comparison of caprine arthritis encephalitis and ovine progressive pneumonia viruses. J. Virol., 39: 914–919.

    Google Scholar 

  • Dahme, E., Stavrou, D., Deutschlander, N., Arnold, W. and Kaiser, E., 1973. Clinical and pathological findings in a transmissible granulomatous meningoencephalomyelitis in domestic goats. Acta. Neuropath., 23: 59–76.

    Google Scholar 

  • Dawson, M., Jeffrey, M., Chasey, D., Venables, C. and Sharp, J. M., 1983. Isolation of a syncytium-forming virus from a goat with polyarthritis. Vet. Rec., 112: 319–321.

    Google Scholar 

  • Delbarre, F., Stunzi, H., Laoussadi, S. and Carlioz, A., 1981. Chronic polyarthrosynovitis in the goat: Histological and physico-chemical study of an animal model of rheumatism with apatite crystals. Comptes Rendus des Seances de l'Academie des Sci., 293: 215–220.

    Google Scholar 

  • Ellis, J. and DeMartini, J. C., 1983. Retroviral disease in small ruminants: Ovine progressive pneumonia and caprine arthritis-encephalitis. Comp. Cont. Educt. Pract. Vet., 5: S173-S183.

    Google Scholar 

  • Fatzer, R., 1979. Granulomatous encephalomyelitis in young goats in Switzerland. Schweizer Archiv Fur Tierheilkunde., 121: 329–339.

    Google Scholar 

  • Gazit, A., Yaniv, A., Dvir, M., Perk, K., Irving, S. G. and Dahlberg, J. E., 1983. The caprine arthritis-encephalitis virus is a distinct virus within the Lentivirus group. Virol., 124: 192–195.

    Google Scholar 

  • Gee, R. W., 1981. Progressive goat pneumonia syndrome. Aust. Vet. J., 57: 483.

    Google Scholar 

  • Guss, S. B., 1982. Veterinary Column: pasteurizing colostrum. Dairy Goat J., 60: 629.

    Google Scholar 

  • Hakioglu, F., Minbay, A. and Gurel, A., 1974. Studies on a viral encephalo-myelitis of sheep and goats in Turkey. Pendik Vet. Kontrol ve Arastirma Enstitusu Dergisi, 7: 146–203.

    Google Scholar 

  • Hinckley, L. S., 1983. Somatic cell count in relation to caprine mastitis. Vet. Med./Sm. Anim. Clin., 78: 1267–1271.

    Google Scholar 

  • Kapture, J., 1982. Attempt made to raise kids free of CAE: positive results are experienced. United Caprine News, June, 6: 5.

    Google Scholar 

  • Klevjer-Anderson, P. and Cheevers, W. P., 1981. Characterization of the infection of caprine synovial membrane cells by the retrovirus caprine arthritis-encephalitis virus. Virol., 110: 113–119.

    Google Scholar 

  • Knight, A. P. and Jokinen, M. P., 1982. Caprine arthritis-encephalitis. Comp. Cont. Educt. Pract. Vet., 4: S263-S269.

    Google Scholar 

  • Lloyd, S., 1982. Goat medicine and surgery. Br. Vet. J., 138: 70–85.

    Google Scholar 

  • Narayan, O., Clements, J. E., Strandberg, J. D., Cork, L. C. and Griffin, D. E., 1980. Biological characterization of the virus causing leukoencephalitis and arthritis in goats. J. Gen. Virol., 50: 69–79.

    Google Scholar 

  • Norman, S. and Smith, M., 1983. Caprine arthritis-encephalitis: review of the neurologic form in 30 cases. J. Am. Vet. Med. Assoc., 182: 1342–1345.

    Google Scholar 

  • Oliver, R. E., Adams, D. S., Gorham, J. R., Jullan, A. F., McNiven, R. A. and Muir, J., 1982a. Isolation of caprine arthritis-encephalitis virus from a goat. New Zealand Vet. J., 30: 147–149.

    Google Scholar 

  • Oliver, R. E., McNiven, R. A., Julian, A. F. and Poole, W. S., 1982b. Experimental infection of sheep and goats with caprine arthritis-encephalitis virus. New Zealand Vet. J., 30: 158–159.

    Google Scholar 

  • O'Sullivan, B. M., Eaves, F. W., Baxendell, S. A. and Rowan, K. J., 1978. Leucoencephalomyelitis of goat kids. Aust. Vet. J., 54: 479–483.

    Google Scholar 

  • Pointon, A. M., Dobson, K. J., Giesecke, P. R., Davenport, P. K. and Cottew, G. S., 1982. Aetiological aspects of chronic arthritis (big knee) in goats. Aust. Vet. J., 58: 167–168.

    Google Scholar 

  • Roberson, S. M., McGuire, T. C., Klevjer-Anderson, P., Gorham, J. R. and Cheevers, W., 1982. Caprine arthritis-encephalitis virus is distinct from Visna and progressive pneumonia viruses as measured by genome sequence homology. J. Virol., 44: 755–758.

    Google Scholar 

  • Robinson W. F., 1981. Chronic interstitial pneumonia in association with a granulomatous encephalitis in a goat. Aust. Vet. J., 57: 127–131.

    Google Scholar 

  • Russo, P., 1982. Caprine viral enzootic polyarthritis: isolation of the pathogenic agent. Bulletin d'information des Laboratories des Services Vet., No. 8: 59–60.

    Google Scholar 

  • Sherman, D. M., 1978. Viral leukoencephalomyelitis in two Minnesota goats. Vet. Med./Sm. Anim. Clin., 73: 1439–1440.

    Google Scholar 

  • Sherman, D.M., 1983. CAE: caprine arthritis encephalitis—a growing concern. Dairy Goat J., 61: 93, 110, 111, 161.

    Google Scholar 

  • Smith, V. W., Dickson, J., Coackley, W. and Maker, D., 1981. Caprine syncytial retroviruses. Aust. Vet. J., 57: 481–483.

    Google Scholar 

  • Stavrou, D., Deutschlander, N. and Dahme, E., 1969. Granulomatous encephalomyelitis in goats. J. Comp. Path., 79: 393–396.

    Google Scholar 

  • Sudaric, F. and Matuka, S., 1975. Pathological findings in “southern wind disease” (meningoencephalitis) in sheep and goats. Vet. Yugoslavia., 24: 397–401.

    Google Scholar 

  • Summers, B. A., Appel, M. J. G., Greisen, H. A., Ebel, J. G. and deLahunta, A., 1980. Studies on viral leukocecephalomyelitis and swayback in goats. Cornell Vet., 70: 372–390, plus figures.

    Google Scholar 

  • Thomson, R. G., 1981. Viral leukoencephalomyelitis-arthritis of goats.Can. Vet. J., 22: 358.

    Google Scholar 

  • Wilkie, I. W., 1980. Leukomyelitis in the goat: a report of three cases. Can. Vet. J., 21: 203–205.

    Google Scholar 

  • Williams, C. S. F., 1979. Viral leukoencephalomyelitis in a goat in Michigan. Vet. Med./Sm. Anim. Clin., 74: 9.

    Google Scholar 

  • Woodard, J. C., Gaskin, J. M., Poulos, P. W., MacKay, R. J. and Burridge, M. J., 1982. Caprine arthritis-encephalitis: clinicopathologic study. Am. J. Vet. Res., 43: 2085–2096.

    Google Scholar 

  • Zimmer, M. and Thedford, T. R., 1981. Caprine arthritis-encephalitis syndrome in Oklahoma goats. Oklahoma Vet. Med. Assoc., 33: 16–17.

    Google Scholar 

  • Zwahlen, R., Aeschbacher, M., Baker, Th., Stucki, M., Wyder-Walteer, M., Weiss, M. and Steck, F., 1983. Lentivirusinfektionen bei zeigen mit carpitis und interstitieller mastitis. Schweiz. Arch. Tierheilk., 125: 281–299.

    Google Scholar 

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Authors and Affiliations

  1. Department of Medicine and Therapeutics, College of Veterinary Medicine, University of Baghdad, Iraq

    F. K. Al-Ani

  2. Department of Surgery and Medicine, College of Veterinary Medicine, Kansas State University, 66506, Manhattan, Kansas, U.S.A.

    J. G. E. Vestweber

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  1. F. K. Al-Ani
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  2. J. G. E. Vestweber
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Kansas Agriculture Experiment Station Contribution #84-148-J.

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Al-Ani, F.K., Vestweber, J.G.E. Caprine arthritis-encephalitis syndrome (CAE): A review. Vet Res Commun 8, 243–253 (1984). https://doi.org/10.1007/BF02214719

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