Abstract
Homologous fibroblasts were injected into vitrectomized rabbit eyes. This injection produced a total retinal detachment in all ten eyes of a control series. In each case the detachment was due to the contraction of a membrane which had grown on the retinal surface as seen in human proliferative vitreoretinopathy (PVR). In another group of ten eyes, silicone oil was injected before the fibroblastic membrane contracted, and removed again a few weeks later. This temporary tamponade of silicone oil reduced the rate of detachment to 50%. Silicone oil did not prevent the preretinal membrane from growing but mechanically decreased its contraction.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Fastenberg DM, Diddle KR, Sorgente N, Ryan SJ (1982) A comparison of different cellular inocula in an experimental model of massive periretinal proliferation. Am J Ophthalmol 93:559–564
Fastenberg DM, Diddle KR, Dorey K, Ryan SJ (1982) The role of cellular proliferation in an experimental model of massive periretinal proliferation. Am J Ophthalmol 93: 565–572
Gonvers M (1982) Temporary use of intraocular silicone oil in the treatment of detachment with massive periretinal proliferation. Preliminary report. Ophthalmologica 184:210–218
Kampik A, Kenyon KR, Michels RG, Green WR, DeLaCruz ZC (1981) Epiretinal and vitreous membranes. Comparative study of 56 cases. Arch Ophthalmol 99:1445–1454
Laqua H, Machemer R (1975) Glial cell proliferation in retinal detachment (massive periretinal proliferation). Am J Ophthalmol 80:602–618
Laqua H, Machemer R (1975) Clinical-pathological correlation in massive periretinal proliferation. Am J Ophthalmol 80:913–929
Leaver PK, Grey RHB, Garner A (1979) Silicone oil injection in the treatment of massive periretinal retraction. II. Late complications in 93 eyes. Br J Ophthalmol 63:361–367
Machemer R (1977) Massive periretinal proliferation: A logical approach to therapy. Trans Amer Ophthalmol Soc 125:556–586
Machemer R (1982) Therapy of massive periretinal proliferation with closed vitrectomy. Int Ophthalmol 2:p 85
Machemer R, Laqua H (1975) Pigment epithelial proliferation in retinal detachment (massive periretinal proliferation). Am J Ophthalmol 80:1–23
Ophir A, Blumenkranz MS, Claflin AJ (1982) Experimental intraocular proliferation and neovascularization. Am J Ophthalmol 94:450–457
Radtke ND, Tano Y, Chandler D, Machemer R (1981) Simulation of massive periretinal proliferation by autotransplantation of retinal pigment epithelial cells in rabbits. Am J Ophthalmol 91:76–87
Scott JD (1979) A rationale for the use of liquid silicone in retinal detachment surgery. In: Acta XXIII Concilium Ophthalmol, Part I, Kyoto, 1978. Excerpta Medica, Amsterdam, pp 433–437
Stern W, Fisher S, Anderson D, O'Donnell J, Erikson P, Lewis G, Gverin C, Borgula G, McDermott M (1982) Epiretinal membrane formation after vitrectomy. Am J Ophthalmol 93:757–772
Sugita G, Tano Y, Machemer R, Abrams G, Claflin AJ, Fiorentino G (1980) Intravitreal autotransplantation of fibroblasts. Am J Ophthalmol 89: 121
Author information
Authors and Affiliations
Additional information
This study was supported in part by a grant from the Schweizerischer Fonds zur Verhütung und Bekämpfung der Blindheit and in part by a grant from the Research to Prevent Blindness, Inc.
Rights and permissions
About this article
Cite this article
Gonvers, M., Thresher, R. Temporary use of silicone oil in the treatment of proliferative vitreoretinopathy. Graefe's Arch Clin Exp Ophthalmol 221, 46–53 (1983). https://doi.org/10.1007/BF02171731
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02171731