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Woodchuck hepatitis virus infection: Serologic and histopathologic course and outcome

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Abstract

Five out of seven American woodchucks inoculated with woodchuck hepatitis virus developed antigenemia after 2 to 13 weeks followed by an antibody response. One animal became a carrier, and another animal exhibited a primary antibody response. Clinical disease was not obvious and aminotransferase elevation could not be demonstrated. Liver biopsy showed mononuclear portal infiltration and little parenchymal cell necrosis.

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References

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Authors and Affiliations

  1. Faculté de Médecine Alexis Carrel, INSERM Unité de Recherche sur les Hepatites et le Role de Virus Hepatotrops dans l'Oncogenese (U271), Rue Paradin, 69372, Lyon, France

    J. Lindberg, C. Pichoud, O. Hantz, L. Vitvitski, D. Frommel & C. Trepo

  2. Laboratorie d'Anatomie Pathologique, Institut Pasteur, ERA/CNRS, Lyon

    J. A. Grimaud

  3. Chaire des Maladies Infectieuses, Ecole National Vétérinaire, 69 Marcy L'Etiole, France

    J. M. Gilbert & L. Joubert

Authors
  1. J. Lindberg
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  2. C. Pichoud
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  3. O. Hantz
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  4. L. Vitvitski
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  5. J. A. Grimaud
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  6. J. M. Gilbert
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  7. L. Joubert
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  8. D. Frommel
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  9. C. Trepo
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Lindberg, J., Pichoud, C., Hantz, O. et al. Woodchuck hepatitis virus infection: Serologic and histopathologic course and outcome. Eur. J, Clin. Microbiol. 4, 59–61 (1985). https://doi.org/10.1007/BF02148663

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  • DOI: https://doi.org/10.1007/BF02148663

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