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Different clinical presentations of a lupus anticoagulant in the same family

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Summary

A young man who had suffered several episodes of deep-vein thrombosis of the legs since the age of 20 had a myocardial infarction at the age of 33, at which time both a prolonged partial thromboplastin time (PTT), compatible with a lupus anticoagulant (LA), and decreased fibrinolytic capacity (FC) were found.

His sister presented with deep-vein thrombosis of a leg and subsequent pulmonary embolism when she was 18 years old. She had a miscarriage three years later and developed a hemolytic-uremic syndrome at the age of 35. The PT and FC were normal. Laboratory investigations of the parents revealed positive antinuclear antibodies in the mother's serum but no anomaly in the father.

This study suggests a familial tendency to develop autoimmune disorders associated with LA and thromboembolic complications related to decreased FC.

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Abbreviations

PTT:

Partial thromboplastin time

FC:

Fibrinolytic capacity

LA:

Lupus anticoagulant

TT:

Thrombin time

PT:

Prothrombin time

GPL:

Anticardiolipin antibodies IgG type

MPL:

Anticardiolipin antibodies IgM type

PC/FII:

Protein C/Factor II

PC/FX:

Protein C/Factor X

FII:

Factor II

FX:

Factor X

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Authors and Affiliations

  1. Département de Médecine interne, Hôpital de la Ville, La Chaux-de-Fonds

    R. -M. Jolidon MD, L. Humair & A. de Torrente

  2. Laboratoire central d'Hématologie, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland

    H. Knecht

  3. Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, CH-1011, Lausanne, Switzerland

    R. -M. Jolidon MD

Authors
  1. R. -M. Jolidon MD
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  2. H. Knecht
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  3. L. Humair
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  4. A. de Torrente
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Jolidon, R.M., Knecht, H., Humair, L. et al. Different clinical presentations of a lupus anticoagulant in the same family. Klin Wochenschr 69, 340–344 (1991). https://doi.org/10.1007/BF02115779

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  • DOI: https://doi.org/10.1007/BF02115779

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