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Primary antral gastritis in young American children

Low prevalence ofHelicobacter pylori infections

  • Esophageal, Gastric, And Duodenal Disorders
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Abstract

AlthoughHelicobacter pylori (H. pylori) is considered by many to be the major cause of primary antral gastritis (PAG), several important questions concerning its pathogenetic role remain unanswered. The most basic unresolved issue relates to the low prevalence ofH. pylori in children in developed countries. IfH. pylori is the cause of PAG, the prevalence of PAG should also be low, but previous studies have not provided data on this issue. To answer this question, we prospectively studied 408 children who underwent esophagogastroduodenoscopy and biopsy from January 1, 1988, to December 31, 1990, for symptoms consistent with peptic disease or immunocompromise. Although the prevalence of PAG was similar (about 20%) in the four age groups of patients studied (<5, 5–9, 10–14, and 15–20 years), the prevalence ofH. pylori infections was significantly greater in the oldest age group (67%,P<0.0001). Only four of 39 children <10 years old with PAG had evidence ofH. pylori. H. pylori is an uncommon finding in our population of young American children with PAG, indicating that it does not play an important role in the pathogenesis of this disorder in this age group.

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Authors and Affiliations

  1. From the Department of Pediatrics and Pathology, Children's Hospital and Harvard Medical School, Boston, Massachusetts

    John D. Snyder MD, Stephen C. Hard MD, Grace M. Thorne PhD, Barry Z. Hirsch MD & Donald A. Antonioli MD

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  1. John D. Snyder MD
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  2. Stephen C. Hard MD
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  3. Grace M. Thorne PhD
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  4. Barry Z. Hirsch MD
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  5. Donald A. Antonioli MD
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Snyder, J.D., Hard, S.C., Thorne, G.M. et al. Primary antral gastritis in young American children. Digest Dis Sci 39, 1859–1863 (1994). https://doi.org/10.1007/BF02088115

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  • DOI: https://doi.org/10.1007/BF02088115

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