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Gastric mucosal plasminogen activators inHelicobacter pylori infection

  • Esophageal, Gastric, And Duodenal Disorders
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Abstract

Long-termH. pylori associated gastritis is recognized as a pathogenic factor in gastric carcinogenesis. In gastric carcinomas the amount and activity of the tissue-type plasminogen activator (t-PA) have been reported to be decreased, whereas those of the urokinase-type plasminogen activator (u-PA) were increased, contributing to the neoplastic and invasive process. The present study was performed to determine t-PA and u-PA levels and activity in gastric mucosa from 102 patients and to investigate whether these levels are influenced byH. pylori infection. The antigen concentration and activity of t-PA and u-PA in corpus mucosa were low (P<0.001) compared with those in antral mucosa, although for the u-PA activity this did not reach statistical significance. InH. pylori-associated antral gastritis the mucosal t-PA antigen concentration and activity were found to be decreased (P<0.001) compared with normal mucosa, whereas inH. pylori-associated pangastritis the corpus t-PA levels were not affected. The antigen concentration and activity of u-PA were found to be significantly (P<0.005) increased, both inH. pylori-associated gastritis of antrum and corpus mucosa. Levels of u-PA in histologically normal corpus mucosa of patients with anH. pylori-associated antral gastritis were also found to be increased (P<0.05). In conclusion, the alterations in the plasminogen activator profile found inH. pylori-associated gastritis, ie, a decrease in t-PA and an increase in u-PA, show a similar tendency as the previously found alterations in gastric carcinomas, which provides additional support for the possible involvement ofH. pylori-associated gastritis in the pathogenesis of gastric carcinoma.

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Authors and Affiliations

  1. Department of Gastroenterology and Hepatology, University Hospital Leiden, Building 1, C4-P, PO Box 9600, 2300 RC, Leiden, The Netherlands

    Jan Mark Götz MD, Yvonne Vergouwe BSc, Hein W. Verspaget MSc, PhD, Izäk Biemond MSc, PhD, Cornelis F. M. Sier MSc, PhD, Cornelis B. H. W. Lamers MD, PhD & Roelof A. Veenendaal MD, PhD

Authors
  1. Jan Mark Götz MD
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  2. Yvonne Vergouwe BSc
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  3. Hein W. Verspaget MSc, PhD
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  4. Izäk Biemond MSc, PhD
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  5. Cornelis F. M. Sier MSc, PhD
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  6. Cornelis B. H. W. Lamers MD, PhD
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  7. Roelof A. Veenendaal MD, PhD
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Götz, J.M., Vergouwe, Y., Verspaget, H.W. et al. Gastric mucosal plasminogen activators inHelicobacter pylori infection. Digest Dis Sci 41, 1577–1582 (1996). https://doi.org/10.1007/BF02087903

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  • DOI: https://doi.org/10.1007/BF02087903

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