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Effect of α1-adrenergic blockade on canine ileal water, electrolyte, and glucose absorption

  • Motility, Nerve-Gut Interactions, Hormones, And Receptors
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Abstract

Meal ingestion stimulates an increase in small intestinal water and electrolyte absorption. Endogenous norepinephrine may at least partially mediate this meal-stimulated proabsorptive response. Luminally administered α1-adrenergic agonists such as norepinephrine and phenylephrine cause significant small bowel absorption, which can be prevented by the selective α1-adrenergic antagonist terazosin. This study tested two hypotheses: (1) a meal stimulates ileal water, electrolyte, and glucose absorption; and (2) meal-stimulated ileal absorption is mediated via α1-adrenergic receptor activation. Absorption studies (N=27) were performed on dogs with 25-cm ileal Thiry-Vella fistulas (TVF). Perfusion with [14C]PEG was used to calculate absorption of water, electrolytes, and glucose from the TVF. Three groups were randomly studied over 4 hr: (1) terazosin alone, (2) meal alone, and (3) terazosin plus meal. Terazosin (10−4 M) was administered to the TVF in groups 1 and 3 following the first hour. A 480-kcal mixed canine meal was ingested at the end of the second hour in groups 2 and 3. Ileal water, electrolyte, and glucose absorption increased significantly in response to meal ingestion (P<0.05). Luminal terazosin did not significantly alter basal or meal-stimulated ileal absorption. In conclusion, meal ingestion stimulates ileal absorption of water, electrolytes, and glucose. Neither basal nor meal-stimulated ileal absorption is altered by α1-adrenergic receptor blockade. These data suggest that nonadrenergic neural pathways or humoral factors are the likely mediators of meal-induced intestinal absorption.

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Authors and Affiliations

  1. Department of Surgery, Blalock 606, Johns Hopkins Hospital, 600 N. Wolfe Street, 21287-4606, Baltimore, Maryland

    M. Kevin Barry MD, Jacqueline D. Gontarek BA, Sean P. Pickering BA &  Charles J. Yeo MD

Authors
  1. M. Kevin Barry MD
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  2. Jacqueline D. Gontarek BA
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  3. Sean P. Pickering BA
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  4. Charles J. Yeo MD
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Additional information

Presented in part at a poster session of the Annual Meeting of The American Gastroenterological Association, Boston, Massachusetts, May 1993. Published in abstract form inGastroenterology 104:A608, 1993.

Supported in part by National Institutes of Health grant R29-DK41178 (C.J.Y.)

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Barry, M.K., Gontarek, J.D., Pickering, S.P. et al. Effect of α1-adrenergic blockade on canine ileal water, electrolyte, and glucose absorption. Digest Dis Sci 39, 2368–2375 (1994). https://doi.org/10.1007/BF02087653

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  • DOI: https://doi.org/10.1007/BF02087653

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