Abstract
Pigmented rabbits were treated with timolol maleate, betaxolol hydrochloride or levobunolol hydrochloride eye drops twice a day for six months. Animals of the same age group and breed were used as controls. There were no differences observed in corneal epithelium with light and transmission electron microscopy. With scanning electron microscopy, in the timolol and betaxolol treated animals the picture of the corneal surface was similar to that of normal rabbit corneas after exposure to air. In scanning electron micrographs of the levobunolol treated animals, the corneal surface resembled the corneas of normal rabbits treated with artificial tears.
Similar content being viewed by others
References
Arthur BW, Hay GJ, Wasan SM, Willis WE. Ultrastructural Effects of Topical Timolol on the Rabbit Cornea. AMA Arch Ophthal 101: 1607–1610, 1983
Brewitt H, Honegger H, Konitz H. Rasterelektronen-mikroskopische Untersuchungen über die Austrocknung des Hornhautepithels und die Wirkung von Tränenersatzflüssigkeiten. Klin Mbl Augenheilk 175: 521–529, 1979
Liu GS, Basu PK, Trope GE. Ultrastructural Changes of the Rabbit Corneal Epithelium and Endothelium After Timoptic Treatment. Graefe's Arch clin exp Ophthal 225: 325–330, 1987
Varga M, Follmann P. Feinstrukturelle Untersuchungen der Bindehautoberfläche nach Langzeitbehandlung mit Timolol. Fortschr Ophthal 83: 155–157, 1986
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Follmann, P., Varga, M. & Daróczy, J. The effect of timolol, betaxolol and levobunolol on the surface of rabbit cornea. Int Ophthalmol 13, 81–84 (1989). https://doi.org/10.1007/BF02028643
Issue Date:
DOI: https://doi.org/10.1007/BF02028643