Abstract
pCMB-Dextran T 10, a large, non-penetrating, SH-blocking reagent caused a reversible amplification of bradykinin sensitivity in the isolated rat uterus. High concentrations of this compound (1×10−3 M) can evoke spontaneous uterus contraction. pCMB-Dextran T 10 did not alter the biological activity of bradykinin. It is assumed that superficial membrane SH-groups are involved in the uterus contraction mechanism.
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References
G. P. Lewis,Active Polypeptides Derived from Plasma Proteins, Physiol. Rev.40, 647–676 (1960).
E. G. Erdös andJ. R. Wohler,Inhibition in vivo of the Enzymatic Inactivation of Bradykinin and Kallidin, Biochem. Pharmac.12, 1193–1199 (1963).
E. Werle, K. Hochstrasser, I. Trautschold andG. Leysath,Wirkung von Thiolglykolsäure auf Kininogen und Kininase, Z. physiol. Chem.337, 286–288 (1964).
S. H. Ferreira andM. Rocha e Silva,Potentiation of Bradykinin by Dimercaptopropanol (BAL) and other Inhibitors of its Destroying Enzyme in Plasma, Biochem. Pharmac.11, 1123–1128 (1962).
B. Simon, G. Zimmerschied E. Kinne-Saffran andR. Kinne,Properties of a Synthetic Plasma Membrane Marker: Fluorescent-Mercury-Dextran, J. Membr. Biol.14, 85–93 (1973).
Z. P. Picarelli, O. B. Henriques andM. C. F. Oliviera,Potentiation of Bradykinin Action on Smooth-Muscle by Cysteine, Experientia18, 77–79 (1962).
M. Cirstea,Potentiation of some Bradykinin Effects by Thiol Compounds, Br. J. Pharmac.25, 405–409 (1965).
D. A. Tewksbury,Studies on the Mechanism of Bradykinin Potentiation, Arch. int. Pharmacodyn.173, 426–432 (1968).
W. Auerswald andW. Doleschel,On the Potentiation of Kinins by Sulfhydrylic Compounds, Arch. int. Pharmacodyn.168, 188–198 (1967).
D. E. Potter andE. J. Walasek,Potentiation of the Bradykinin Response by Cysteine: Mechanism of Action, Arch. int. Pharmacodyn.197, 338–349 (1972).
J. K. Ullrich, H. Fasold, S. Klöss, G. Rumrich, M. Salzer, K. Sato, B. Simon andI. X. de Vries,Effect of SH-, NH 2 - and COOH-Site Group Reagents on the Transport Processes in the Proximal Convolution of the Rat Kidney, Pflügers Arch. Ges. Physiol.344, 51–68 (1973).
V. Wizemann, I. Schulz andB. Simon,SH-Groups on the Surface of Pancreas Involved in Secretin Stimulation and Glucose-Mediated Secretion, Biochim. Biophys. Acta307, 366–371 (1973).
H. Kather andB. Simon,Studies on the Role of Superficial Fat Cell SH-Groups in Glucose Uptake, Horm. Metab. Res.7, 98–99 (1975).
H. Kather, B. Simon andM. Geiger,Orientation of SH-Groups Related to Hormone and NaF Stimulated Adenylate Cyclase within the Fat Cell Membrane, Horm. Metab. Res., in press (1975).
B. Simon andH. Kather,pCMB-Dextran T 10: A Useful Tool in Evaluating the Functional Importance of Superficial SH-Groups in Rat Adipocytes, Agents and Actions,7 215–217 (1975).
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Mann, K., Bachhuber, F., Kather, H. et al. Amplification of the bradykinin response in rat uterus by pCMB-dextran T 10. Agents and Actions 5, 236–238 (1975). https://doi.org/10.1007/BF02026437
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DOI: https://doi.org/10.1007/BF02026437