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Modulation of morphine-induced antinociception in mice by histamine H3-receptor ligands

  • Histamine and the Central Nervous System
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Abstract

The effects of compounds active at histamine H3-receptors on morphine-induced antinociception have been investigated in thermal and chemical tests in mice; tail-immersion (50°C) and hot-plate (49° and 55°C) tests and acetic acid-induced writhing. Neither (R)α-methylhistamine, a specific agonist, (S)α-methylhistamine, a chemical control, nor thioperamide, an antagonist, had any antinociceptive action alone but thioperamide (3 mg kg−1) attenuated the effects of morphine in the tailimmersion test wile (R)α-methylhistamine (1 mg kg−1), but not the (S) isomer, potentiated its effects in the hot-plate test at 55°C. These results are consistent with the morphine potentiation seen with H1-antagonists and suggest that central histaminergic mechanisms can modulate opioid actions.

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Authors and Affiliations

  1. Neuropharmacology Research Group, Department of Life Sciences, University of East London, Romford Road., E15 4LZ, London, U.K.

    S. M. Owen, G. Sturman & P. Freeman

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  1. S. M. Owen
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  2. G. Sturman
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  3. P. Freeman
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Owen, S.M., Sturman, G. & Freeman, P. Modulation of morphine-induced antinociception in mice by histamine H3-receptor ligands. Agents and Actions 41 (Suppl 1), C62–C63 (1994). https://doi.org/10.1007/BF02007768

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  • DOI: https://doi.org/10.1007/BF02007768

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