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Involvement of the catecholaminergic system in the inhibitory effect of brain histamine on growth hormone secretion

  • Histamine and the Nervous System
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Abstract

The effects of intracerebroventricular (icv) injection of histamine (HA, 0.4 μmol/rat) or of the inhibitor of HA synthesisα-fluoromethylhistidine (αFMH, 100 mg/kg, intracarotid (ia)) on growth hormone (GH) secretion induced by GH-releasing hormone (hGHRH1–40, 2 μg/kg, ia) in freely moving rats were examined. HA significantly inhibited GH release induced by GHRH whereas pretreatment (3 h before) with αFMH enhanced the GH response to GHRH.

The inhibitory effect of HA on GHRH-induced GH release is still evident in somatostatin-depleted rats with cysteamine (300 mg/kg, sc, 4 h before) but is completely overcome by the inhibitor of catecholamine synthesis (α-methyl-p-tyrosine, 200 mg/kg, ip, 2 h before) suggesting that HA influences GH secretion by modulation of catecholaminergic neurons. This suggestion is supported by the biochemical data showing an increase in noradrenaline and dopamine contents in the hypothalamus and striatum of rats pretreated with αFMH.

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References

  1. C. Netti, F. Guidobono, V. R. Olgiati, V. Sibilia, F. Pagani and A. Pecile,Influence of brain histaminergic system on episodic growth hormone secretion in the rat. Neuroendocrinology35, 43–47 (1982).

    PubMed  Google Scholar 

  2. L. C. Terry, W. R. Crowley and M. D. Johnson,Regulation of episodic growth hormone secretion by the central epinephrine system. J. Clin. Invest.69, 104–112 (1982).

    PubMed  Google Scholar 

  3. N. Subramanian and A. H. Mulder,Modulation of histamine efflux of radiolabelled catecholamines from rat brain slices. Eur. J. Pharmacol.43, 143–152 (1977).

    PubMed  Google Scholar 

  4. E. Schlicker, K. Fink, M. Hinterthaner and M. Gothert,Inhibition of noradrenaline release in the rat brain cortex via presynaptic H 3 receptors. Naunyn-Schmiedeberg's Arch. Pharmacol.340, 633–638 (1989).

    Google Scholar 

  5. C. Kotake, T. Heffner, G. Vosmer and L. Seiden,Determination of dopamine, norepinephrine, serotonin and their major metabolic products in rat brain by reverse-phase ion-pair high performance liquid chromatography with electrochemical detection. Pharmacol. Biochem. Behavior.22, 85–89 (1989).

    Google Scholar 

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Authors and Affiliations

  1. Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milan, Via Vanvitelli 32, 20129, Milan, Italy

    V. Sibilia, F. Guidobono, A. Pecile, F. Pagani, I. Villa & C. Netti

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  1. V. Sibilia
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  2. F. Guidobono
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  3. A. Pecile
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  4. F. Pagani
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  5. I. Villa
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  6. C. Netti
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Sibilia, V., Guidobono, F., Pecile, A. et al. Involvement of the catecholaminergic system in the inhibitory effect of brain histamine on growth hormone secretion. Agents and Actions 38, C272–C274 (1993). https://doi.org/10.1007/BF01996483

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  • DOI: https://doi.org/10.1007/BF01996483

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