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Interleukin-1-induced cartilage degradation is independent of substance P level in rabbit knees

  • Osteoarthritis
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Abstract

The effect of SP on recombinant human IL-1α-induced cartilage degradation in rabbit knees was investigated. Co-injection of 10 ng IL-1 and 1 μg SP did not increase cartilage degradation above the level observed after injection of 10 ng IL-1 alone. Co-injection of 100 ng IL-1 and 150 μg Spantide, a potent SP antagonist, did not reduce the level of cartilage degradation. Infusion of 100 ng SP/day for two weeks did not induce cartilage degradation. These observations suggest that cartilage degradation induced by IL-1 is independent of SP concentrations in rabbit knees.

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Authors and Affiliations

  1. Pharmaceuticals Division, Research Department, CIBA-GEIGY Corporation, 556 Morris Ave., 07901, Summit, NJ, USA

    E. M. O'Byrne, R. L. Goldberg, J. R. Doughty, M. Wong, V. Blancuzzi, D. Wilson & A. Y. Jeng

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  1. E. M. O'Byrne
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  2. R. L. Goldberg
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  3. J. R. Doughty
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  4. M. Wong
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  5. V. Blancuzzi
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  6. D. Wilson
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  7. A. Y. Jeng
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O'Byrne, E.M., Goldberg, R.L., Doughty, J.R. et al. Interleukin-1-induced cartilage degradation is independent of substance P level in rabbit knees. Agents and Actions 34, 232–234 (1991). https://doi.org/10.1007/BF01993289

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  • DOI: https://doi.org/10.1007/BF01993289

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