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Misoprostol attenuates acetic acid-induced damage in rabbit distal small intestine

  • Non-Rheumatic Inflammatory Diseases
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Abstract

The influence of misoprostol pretreatment (100 μg/loop intraluminally) on small intestinal damage induced by acetic acid was evaluated in anesthetized rabbits. In this model injury was induced by intraluminal administration into loops of distal small intestine, of a solution of calcium gluconate (50 mg/ml) and acetic (200 mM). After 3 hr damage was associated with increase in loop fluid volume, loop fluid protein levels and epithelial permeability to51Cr-EDTA, all of which were attenuated by misoprostol pretreatment. Similar protective effects were noted 45 min after the insult, suggesting that misoprostol may be therapeutically useful in conditions where the epithelial barrier is compromised.

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Authors and Affiliations

  1. Department of Pediatrics, Louisiana State University, School of Medicine, 1542 Tulane Ave., 70112-2822, New Orleans, Louisiana, USA

    M. J. S. Miller, X. -J. Zhang, X. Gu, H. Sadowska-Krowicka & D. A. Clark

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  1. M. J. S. Miller
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  2. X. -J. Zhang
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  3. X. Gu
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  4. H. Sadowska-Krowicka
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  5. D. A. Clark
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Miller, M.J.S., Zhang, X.J., Gu, X. et al. Misoprostol attenuates acetic acid-induced damage in rabbit distal small intestine. Agents and Actions 34, 185–186 (1991). https://doi.org/10.1007/BF01993273

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  • DOI: https://doi.org/10.1007/BF01993273

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