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Lack of specific saxitoxin binding to rat mast cells

  • Histamine Release from Mast Cells and Basophils
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Abstract

We studied whether or not mast cells are endowed with specific sodium channels, by using tritiated saxitoxin which binds to site 1 of sodium channels on excitable tissues. Our results suggest that rat pleural and peritoneal mast cells lack specific sodium channels.

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Author notes

  1. L. M. Botana

    Present address: Unit Office 2, Johns Hopkins Asthma and Allergy Center, 301 Bayview Boulevard, 21224, Baltimore, MD, USA

Authors and Affiliations

  1. Departamentos de Farmacología y Fisiología, Facultad de Veterinaria, Universidad de Santiago de Compostela, E-27002, Lugo, Spain

    M. R. Vieytes, M. C. Louzao, M. J. Bujan, A. Alfonso, A. Cabado, L. F. de la Cruz & L. M. Botana

Authors
  1. M. R. Vieytes
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  2. M. C. Louzao
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  3. M. J. Bujan
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  4. A. Alfonso
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  5. A. Cabado
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  6. L. F. de la Cruz
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  7. L. M. Botana
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Vieytes, M.R., Louzao, M.C., Bujan, M.J. et al. Lack of specific saxitoxin binding to rat mast cells. Agents and Actions 33, 92–93 (1991). https://doi.org/10.1007/BF01993135

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  • DOI: https://doi.org/10.1007/BF01993135

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